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MetaCyc Reaction: 2.3.1.192

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.192

Enzymes and Genes:

Bos taurus : phenylacetyl-coenzyme A:glycine N-acyltransferase Inferred from experiment : GAT

In Pathway: L-phenylalanine degradation IV (mammalian, via side chain)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glycine N-phenylacetyltransferase

Enzyme Commission Synonyms: arylacetyl-CoA N-acyltransferase, arylacetyltransferase, GAT (gene name)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -5.0441284 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Not identical with EC 2.3.1.13 (glycine N-acyltransferase). This enzyme was purified from bovine liver mitochondria. L-asparagine, L-glutamine and L-arginine are also substrates, but have higher Km values.

Citations: [Nandi79, Kelley90, Vessey98]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R05841 , Rhea:27850

Relationship Links: BRENDA:EC:2.3.1.192 , ENZYME:EC:2.3.1.192 , IUBMB-ExplorEnz:EC:2.3.1.192

Credits:
Created 20-Aug-2009 by Fulcher CA , SRI International
Revised 03-Nov-2010 by Caspi R , SRI International


References

Kelley90: Kelley M, Vessey DA (1990). "The effects of ions on the conjugation of xenobiotics by the aralkyl-CoA and arylacetyl-CoA N-acyltransferases from bovine liver mitochondria." J Biochem Toxicol 5(2);125-35. PMID: 2283662

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nandi79: Nandi DL, Lucas SV, Webster LT (1979). "Benzoyl-coenzyme A:glycine N-acyltransferase and phenylacetyl-coenzyme A:glycine N-acyltransferase from bovine liver mitochondria. Purification and characterization." J Biol Chem 254(15);7230-7. PMID: 457678

Vessey98: Vessey DA, Lau E (1998). "Determination of the sequence of the arylacetyl acyl-CoA:amino acid N-acyltransferase from bovine liver mitochondria and its homology to the aralkyl acyl-CoA:amino acid N-acyltransferase." J Biochem Mol Toxicol 12(5);275-9. PMID: 9664233


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue May 26, 2015, biocyc14.