MetaCyc Reaction: [no EC number assigned]

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsComposite Reactions
Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Marked as unbalanced.

strictosamide + an unknown oxygen source → pumiloside,
pumiloside → deoxypumiloside,
deoxypumiloside → camptothecin

Standard Gibbs Free Energy (ΔrG in kcal/mol): -81.93366Inferred by computational analysis [Latendresse13]

This is a hypothetical reaction, it is possible there are several intermediary steps between strictosamide and camptothecin [Yamazaki03].


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Yamazaki03: Yamazaki Y, Urano A, Sudo H, Kitajima M, Takayama H, Yamazaki M, Aimi N, Saito K (2003). "Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants." Phytochemistry 62(3);461-70. PMID: 12620359

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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