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discounted registration ends Sept 5, 2015
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MetaCyc Reaction: [no EC number assigned]

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Composite Reactions
Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Marked as unbalanced.

Sub-reactions:
strictosamide + an unknown oxygen source → pumiloside ,
pumiloside → deoxypumiloside ,
deoxypumiloside → camptothecin

Standard Gibbs Free Energy (ΔrG in kcal/mol): -81.93366 Inferred by computational analysis [Latendresse13]

Summary:
This is a hypothetical reaction, it is possible there are several intermediary steps between strictosamide and camptothecin [Yamazaki03].


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Yamazaki03: Yamazaki Y, Urano A, Sudo H, Kitajima M, Takayama H, Yamazaki M, Aimi N, Saito K (2003). "Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants." Phytochemistry 62(3);461-70. PMID: 12620359


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Sep 1, 2015, biocyc11.