MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
diphosphoinositol polyphosphate phosphohydrolase 1 Inferred from experiment : NUDT3 ( Homo sapiens )
diphosphoinositol polyphosphate phosphohydrolase 3α Inferred from experiment : NUDT10 ( Homo sapiens )
diphosphoinositol polyphosphate phosphohydrolase 3β Inferred from experiment : NUDT11 ( Homo sapiens )
diphosphoinositol polyphosphate phosphohydrolase 2 Inferred from experiment : NUDT4 ( Homo sapiens )

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: diphosphoinositol-polyphosphate diphosphatase

Enzyme Commission Synonyms: diphosphoinositol-polyphosphate phosphohydrolase, DIPP

Taxonomic Range: Fungi , Metazoa

Standard Gibbs Free Energy (ΔrG in kcal/mol): -0.57177734 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme hydrolyzes the diphosphate bond, leaving a phospho group where a diphospho group had been.

Citations: [Safrany98, Caffrey00]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Created 28-Oct-2009 by Caspi R , SRI International


Caffrey00: Caffrey JJ, Safrany ST, Yang X, Shears SB (2000). "Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family." J Biol Chem 275(17);12730-6. PMID: 10777568

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Safrany98: Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB (1998). "A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase." EMBO J 17(22);6599-607. PMID: 9822604

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Wed Apr 1, 2015, biocyc12.