|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
|Homo sapiens :||diphosphoinositol polyphosphate phosphohydrolase 2
diphosphoinositol polyphosphate phosphohydrolase 3β : NUDT11
diphosphoinositol polyphosphate phosphohydrolase 3α : NUDT10
diphosphoinositol polyphosphate phosphohydrolase 1 : NUDT3
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: diphosphoinositol-polyphosphate diphosphatase
Enzyme Commission Synonyms: diphosphoinositol-polyphosphate phosphohydrolase, DIPP
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -0.57177734 [Latendresse13]
Enzyme Commission Summary:
This enzyme hydrolyzes the diphosphate bond, leaving a phospho group where a diphospho group had been.
Caffrey00: Caffrey JJ, Safrany ST, Yang X, Shears SB (2000). "Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family." J Biol Chem 275(17);12730-6. PMID: 10777568
Safrany98: Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB (1998). "A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase." EMBO J 17(22);6599-607. PMID: 9822604
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