|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
In Pathway: inositol pyrophosphates biosynthesis
Supersedes EC numbers: 188.8.131.52, 184.108.40.206
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name for 220.127.116.11: inositol-hexakisphosphate kinase
Enzyme Commission Synonyms for 18.104.22.168: ATP:1D-myo-inositol-hexakisphosphate phosphotransferase, IP6K
Enzyme Commission Primary Name for 22.214.171.124: diphosphoinositol-pentakisphosphate kinase
Enzyme Commission Synonyms for 126.96.36.199: PP-IP5 kinase, diphosphoinositol pentakisphosphate kinase, ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase, PP-InsP5 kinase, PPIP5K, PPIP5K1, PPIP5K2, VIP1, VIP2
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -7.0270996 [Latendresse13]
Formerly EC 188.8.131.52.
Enzyme Commission Summary for 184.108.40.206:
This reaction is considered a second official reaction for EC 220.127.116.11.
Three mammalian isoforms are known to exist.
Enzyme Commission Summary for 18.104.22.168:
This enzyme is activated by osmotic shock. D-myo-inositol 1,3,4,5,6-pentakisphosphate, 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate and 1D-myo-inositol bisdiphosphate triphosphate are not substrates [Choi07].
Albert97: Albert C, Safrany ST, Bembenek ME, Reddy KM, Reddy K, Falck J, Brocker M, Shears SB, Mayr GW (1997). "Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells." Biochem J 327 ( Pt 2);553-60. PMID: 9359429
Choi07: Choi JH, Williams J, Cho J, Falck JR, Shears SB (2007). "Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress." J Biol Chem 282(42);30763-75. PMID: 17702752
Fridy07: Fridy PC, Otto JC, Dollins DE, York JD (2007). "Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases." J Biol Chem 282(42);30754-62. PMID: 17690096
Lin09: Lin H, Fridy PC, Ribeiro AA, Choi JH, Barma DK, Vogel G, Falck JR, Shears SB, York JD, Mayr GW (2009). "Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases." J Biol Chem 284(3);1863-72. PMID: 18981179
Saiardi99: Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH (1999). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases." Curr Biol 9(22);1323-6. PMID: 10574768
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