Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.6.1.52

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.6.1.52

Enzymes and Genes:
diphosphoinositol polyphosphate phosphohydrolase 1 : NUDT3 ( Homo sapiens )

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: diphosphoinositol-polyphosphate diphosphatase

Enzyme Commission Synonyms: diphosphoinositol-polyphosphate phosphohydrolase, DIPP

Standard Gibbs Free Energy (ΔrG in kcal/mol): -0.57177734 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme hydrolyzes the diphosphate bond, leaving a phospho group where a diphospho group had been.

Citations: [Safrany98, Caffrey00]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:3.6.1.52 , ENZYME:EC:3.6.1.52 , IUBMB-ExplorEnz:EC:3.6.1.52

Credits:
Created 29-Oct-2009 by Caspi R , SRI International


References

Caffrey00: Caffrey JJ, Safrany ST, Yang X, Shears SB (2000). "Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family." J Biol Chem 275(17);12730-6. PMID: 10777568

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Safrany98: Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB (1998). "A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase." EMBO J 17(22);6599-607. PMID: 9822604


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 20, 2014, BIOCYC14B.