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MetaCyc Reaction: 3.6.1.52

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 3.6.1.52

Enzymes and Genes:

Homo sapiens: diphosphoinositol polyphosphate phosphohydrolase 1: NUDT3

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: diphosphoinositol-polyphosphate diphosphatase

Enzyme Commission Synonyms: diphosphoinositol-polyphosphate phosphohydrolase, DIPP

Taxonomic Range: Fungi, Metazoa

Standard Gibbs Free Energy (ΔrG in kcal/mol): 0.052368164Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme hydrolyzes the diphosphate bond, leaving a phospho group where a diphospho group had been.

Citations: [Safrany98, Caffrey00]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:3.6.1.52, ENZYME:EC:3.6.1.52, IUBMB-ExplorEnz:EC:3.6.1.52

Credits:
Created 29-Oct-2009 by Caspi R, SRI International


References

Caffrey00: Caffrey JJ, Safrany ST, Yang X, Shears SB (2000). "Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family." J Biol Chem 275(17);12730-6. PMID: 10777568

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Safrany98: Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB (1998). "A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase." EMBO J 17(22);6599-607. PMID: 9822604


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Feb 13, 2016, biocyc12.