MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: nitroalkane oxidase

Enzyme Commission Synonyms: nitroethane oxidase, NAO, nitroethane:oxygen oxidoreductase

Taxonomic Range: Fungi

Enzyme Commission Summary:
Has an absolute requirement for FAD [Fitzpatrick05]. While nitroethane may be the physiological substrate [Kido78], the enzyme also acts on several other nitroalkanes, including 1-nitropropane, 2-nitropropane, 1-nitrobutane, 1-nitropentane, 1-nitrohexane, nitrocyclohexane and some nitroalkanols [Fitzpatrick05].

Citations: [Valley05, Daubner02, LITTLE51]

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 30-Nov-2009 by Caspi R, SRI International


Daubner02: Daubner SC, Gadda G, Valley MP, Fitzpatrick PF (2002). "Cloning of nitroalkane oxidase from Fusarium oxysporum identifies a new member of the acyl-CoA dehydrogenase superfamily." Proc Natl Acad Sci U S A 99(5);2702-7. PMID: 11867731

Fitzpatrick05: Fitzpatrick PF, Orville AM, Nagpal A, Valley MP (2005). "Nitroalkane oxidase, a carbanion-forming flavoprotein homologous to acyl-CoA dehydrogenase." Arch Biochem Biophys 433(1);157-65. PMID: 15581574

Kido78: Kido T, Hashizume K, Soda K (1978). "Purification and properties of nitroalkane oxidase from Fusarium oxysporum." J Bacteriol 133(1);53-8. PMID: 22538

LITTLE51: LITTLE HN (1951). "Oxidation of nitroethane by extracts from Neurospora." J Biol Chem 193(1);347-58. PMID: 14907722

Valley05: Valley MP, Tichy SE, Fitzpatrick PF (2005). "Establishing the kinetic competency of the cationic imine intermediate in nitroalkane oxidase." J Am Chem Soc 127(7);2062-6. PMID: 15713081

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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