MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: nitroalkane oxidase

Enzyme Commission Synonyms: nitroethane oxidase, NAO, nitroethane:oxygen oxidoreductase

Taxonomic Range: Fungi

Enzyme Commission Summary:
Has an absolute requirement for FAD [Fitzpatrick05]. While nitroethane may be the physiological substrate [Kido78], the enzyme also acts on several other nitroalkanes, including 1-nitropropane, 2-nitropropane, 1-nitrobutane, 1-nitropentane, 1-nitrohexane, nitrocyclohexane and some nitroalkanols [Fitzpatrick05].

Citations: [Valley05, Daubner02, LITTLE51]

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Created 30-Nov-2009 by Caspi R , SRI International


Daubner02: Daubner SC, Gadda G, Valley MP, Fitzpatrick PF (2002). "Cloning of nitroalkane oxidase from Fusarium oxysporum identifies a new member of the acyl-CoA dehydrogenase superfamily." Proc Natl Acad Sci U S A 99(5);2702-7. PMID: 11867731

Fitzpatrick05: Fitzpatrick PF, Orville AM, Nagpal A, Valley MP (2005). "Nitroalkane oxidase, a carbanion-forming flavoprotein homologous to acyl-CoA dehydrogenase." Arch Biochem Biophys 433(1);157-65. PMID: 15581574

Kido78: Kido T, Hashizume K, Soda K (1978). "Purification and properties of nitroalkane oxidase from Fusarium oxysporum." J Bacteriol 133(1);53-8. PMID: 22538

LITTLE51: LITTLE HN (1951). "Oxidation of nitroethane by extracts from Neurospora." J Biol Chem 193(1);347-58. PMID: 14907722

Valley05: Valley MP, Tichy SE, Fitzpatrick PF (2005). "Establishing the kinetic competency of the cationic imine intermediate in nitroalkane oxidase." J Am Chem Soc 127(7);2062-6. PMID: 15713081

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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