MetaCyc Reaction: 1.1.1.-

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 1.1.1.-

Enzymes and Genes:

Blautia producta K 2/25.1: 3α-hydroxysteroid dehydrogenaseInferred from experiment
Homo sapiens: 3α hydroxysteroid dehydrogenase III: AKR1C2
retinol dehydrogenase 9: DHRS9

In Pathway: glycocholate metabolism (bacteria)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Standard Gibbs Free Energy (ΔrG in kcal/mol): -0.37820435Inferred by computational analysis [Latendresse13]

Citations: [Ridlon06]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [allopregnanolone + NAD(P)+ ↔ 5-α-pregnane-3,20-dione + NAD(P)H + H+] (
i1: allopregnanolone + NAD+ → 5-α-pregnane-3,20-dione + NADH + H+ (1.1.-.-)

i2: allopregnanolone + NADP+ ← 5-α-pregnane-3,20-dione + NADPH + H+ (

Instance reactions of [testosterone + NAD(P)+ → androst-4-ene-3,17-dione + NAD(P)H + H+] (
i3: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+ (

i4: testosterone + NADP+ ← androst-4-ene-3,17-dione + NADPH + H+ (

Created 02-Jun-2010 by Fulcher CA, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Ridlon06: Ridlon JM, Kang DJ, Hylemon PB (2006). "Bile salt biotransformations by human intestinal bacteria." J Lipid Res 47(2);241-59. PMID: 16299351

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Nov 28, 2015, biocyc11.