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MetaCyc Reaction: 1.1.1.-

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.-

Enzymes and Genes:
retinol dehydrogenase 9 : DHRS9 ( Homo sapiens )
3α hydroxysteroid dehydrogenase III : AKR1C2 ( Homo sapiens )
3α-hydroxysteroid dehydrogenase Inferred from experiment ( Blautia producta K 2/25.1 )

In Pathway: glycocholate metabolism (bacteria)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Standard Gibbs Free Energy (ΔrG in kcal/mol): -0.37820435 Inferred by computational analysis [Latendresse13]

Citations: [Ridlon06]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reactions of [allopregnanolone + NAD(P)+ ↔ 5-α-pregnane-3,20-dione + NAD(P)H + H+] (1.1.1.213):
i1: allopregnanolone + NAD+ → 5-α-pregnane-3,20-dione + NADH + H+ (1.1.-.-)

i2: allopregnanolone + NADP+ ← 5-α-pregnane-3,20-dione + NADPH + H+ (1.1.1.278)

Instance reactions of [testosterone + NAD(P)+ → androst-4-ene-3,17-dione + NAD(P)H + H+] (1.1.1.51):
i3: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+ (1.1.1.239)

i4: testosterone + NADP+ ← androst-4-ene-3,17-dione + NADPH + H+ (1.1.1.64)

Credits:
Created 02-Jun-2010 by Fulcher CA , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Ridlon06: Ridlon JM, Kang DJ, Hylemon PB (2006). "Bile salt biotransformations by human intestinal bacteria." J Lipid Res 47(2);241-59. PMID: 16299351


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Mar 30, 2015, biocyc14.