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MetaCyc Reaction: 2.1.1.197

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 2.1.1.197

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: malonyl-[acp] methyltransferaseInferred from experiment: bioC

In Pathway: 8-amino-7-oxononanoate biosynthesis I

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: malonyl-[acyl-carrier protein] O-methyltransferase

Enzyme Commission Synonyms: BioC

Standard Gibbs Free Energy (ΔrG): -34.89514 kcal/molInferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Involved in an early step of biotin biosynthesis in Gram-negative bacteria. This enzyme catalyses the transfer of a methyl group to the ?-carboxyl group of malonyl-CoA forming a methyl ester. The methyl ester is recognized by the fatty acid synthetic enzymes, which process it via the fatty acid elongation cycle to give pimelyl-[acyl-carried-protein] methyl ester [Lin10a].

Citations: [Del67, Rolfe68, Otsuka88, Cleary72]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R09543, Rhea:34899

Relationship Links: BRENDA:EC:2.1.1.197, ENZYME:EC:2.1.1.197, IUBMB-ExplorEnz:EC:2.1.1.197

Credits:
Created 04-Jun-2010 by Caspi R, SRI International


References

Cleary72: Cleary PP, Campbell A (1972). "Deletion and complementation analysis of biotin gene cluster of Escherichia coli." J Bacteriol 112(2);830-9. PMID: 4563978

Del67: Del Campillo-Campbell A, Kayajanian G, Campbell A, Adhya S (1967). "Biotin-requiring mutants of Escherichia coli K-12." J Bacteriol 94(6);2065-6. PMID: 4864413

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lin10a: Lin S, Hanson RE, Cronan JE (2010). "Biotin synthesis begins by hijacking the fatty acid synthetic pathway." Nat Chem Biol 6(9);682-8. PMID: 20693992

Otsuka88: Otsuka AJ, Buoncristiani MR, Howard PK, Flamm J, Johnson C, Yamamoto R, Uchida K, Cook C, Ruppert J, Matsuzaki J (1988). "The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon." J Biol Chem 263(36);19577-85. PMID: 3058702

Rolfe68: Rolfe B, Eisenberg MA (1968). "Genetic and biochemical analysis of the biotin loci of Escherichia coli K-12." J Bacteriol 96(2);515-24. PMID: 4877129


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 20.0 (software by SRI International) on Fri May 6, 2016, BIOCYC14.