Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

MetaCyc Reaction: 2.1.1.197

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.1.1.197

Enzymes and Genes:
malonyl-[acp] methyltransferase Inferred from experiment : bioC ( Escherichia coli K-12 substr. MG1655 )

In Pathway: 8-amino-7-oxononanoate biosynthesis I

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: malonyl-[acyl-carrier protein] O-methyltransferase

Enzyme Commission Synonyms: BioC

Standard Gibbs Free Energy (ΔrG in kcal/mol): -35.519264 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Involved in an early step of biotin biosynthesis in Gram-negative bacteria. This enzyme catalyses the transfer of a methyl group to the ?-carboxyl group of malonyl-CoA forming a methyl ester. The methyl ester is recognized by the fatty acid synthetic enzymes, which process it via the fatty acid elongation cycle to give pimelyl-[acyl-carried-protein] methyl ester [Lin10a].

Citations: [Del67, Rolfe68, Otsuka88, Cleary72]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R09543 , Rhea:34899

Relationship Links: BRENDA:EC:2.1.1.197 , ENZYME:EC:2.1.1.197 , IUBMB-ExplorEnz:EC:2.1.1.197

Credits:
Created 04-Jun-2010 by Caspi R , SRI International


References

Cleary72: Cleary PP, Campbell A (1972). "Deletion and complementation analysis of biotin gene cluster of Escherichia coli." J Bacteriol 112(2);830-9. PMID: 4563978

Del67: Del Campillo-Campbell A, Kayajanian G, Campbell A, Adhya S (1967). "Biotin-requiring mutants of Escherichia coli K-12." J Bacteriol 94(6);2065-6. PMID: 4864413

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lin10a: Lin S, Hanson RE, Cronan JE (2010). "Biotin synthesis begins by hijacking the fatty acid synthetic pathway." Nat Chem Biol 6(9);682-8. PMID: 20693992

Otsuka88: Otsuka AJ, Buoncristiani MR, Howard PK, Flamm J, Johnson C, Yamamoto R, Uchida K, Cook C, Ruppert J, Matsuzaki J (1988). "The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon." J Biol Chem 263(36);19577-85. PMID: 3058702

Rolfe68: Rolfe B, Eisenberg MA (1968). "Genetic and biochemical analysis of the biotin loci of Escherichia coli K-12." J Bacteriol 96(2);515-24. PMID: 4877129


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC13A.