Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.5.1.85

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.5.1.85

Enzymes and Genes:
geranylgeranyl-diphosphate all-trans-nonaprenyl diphosphate synthase Inferred from experiment : SPS1 ( Arabidopsis thaliana col )
geranylgeranyl-diphosphate all-trans-nonaprenyl diphosphate synthase Inferred from experiment : SPS2 ( Arabidopsis thaliana col )

In Pathway: nonaprenyl diphosphate biosynthesis II

Supersedes EC number: 2.5.1.11

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]

Enzyme Commission Synonyms: nonaprenyl diphosphate synthase (ambiguous), solanesyl diphosphate synthase (ambiguous), At-SPS2, At-SPS1, SPS1, SPS2

Standard Gibbs Free Energy (ΔrG in kcal/mol): -64.99988 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Geranylgeranyl diphosphate is preferred over (2E,6E)-farnesyl diphosphate as allylic substrate [Hirooka03]. Arabidopsis thaliana possesses two alleles - AtSPS2 supplies the precursor of the plastoquinone side-chain, while At-SPS1 contributes to the biosynthesis of the ubiquinone side-chain [Hirooka05].

Citations: [Jun04]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R09251 , Rhea:27594

Relationship Links: BRENDA:EC:2.5.1.85 , ENZYME:EC:2.5.1.85 , IUBMB-ExplorEnz:EC:2.5.1.85

Credits:
Created 07-Jun-2010 by Caspi R , SRI International


References

Hirooka03: Hirooka K, Bamba T, Fukusaki E, Kobayashi A (2003). "Cloning and kinetic characterization of Arabidopsis thaliana solanesyl diphosphate synthase." Biochem J 370(Pt 2);679-86. PMID: 12437513

Hirooka05: Hirooka K, Izumi Y, An CI, Nakazawa Y, Fukusaki E, Kobayashi A (2005). "Functional analysis of two solanesyl diphosphate synthases from Arabidopsis thaliana." Biosci Biotechnol Biochem 69(3);592-601. PMID: 15784989

Jun04: Jun L, Saiki R, Tatsumi K, Nakagawa T, Kawamukai M (2004). "Identification and subcellular localization of two solanesyl diphosphate synthases from Arabidopsis thaliana." Plant Cell Physiol 45(12);1882-8. PMID: 15653808

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, BIOCYC14A.