Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 1.5.1.43

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.5.1.43

Enzymes and Genes:
carboxyspermidine dehydrogenase Inferred from experiment : C8J_0166 ( Campylobacter jejuni jejuni 81116 )
carboxynorspermidine dehydrogenase Inferred from experiment ( Vibrio alginolyticus NBRC 15630 = ATCC 17749 )
carboxynorspermidine dehydrogenase Inferred from experiment : VC1624 ( Vibrio cholerae )

In Pathway: spermidine biosynthesis II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: carboxynorspermidine synthase

Enzyme Commission Synonyms: carboxynorspermidine dehydrogenase, carboxyspermidine dehydrogenase, CASDH, CANSDH, VC1624 (gene name)

Standard Gibbs Free Energy (ΔrG in kcal/mol): 4.280487 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The reaction takes place in the opposite direction. Part of a bacterial polyamine biosynthesis pathway. L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a Schiff base that is reduced to form carboxynorspermidine/carboxyspermidine, respectively [Nakao91]. The enzyme from the bacterium Vibrio cholerae is essential for biofilm formation [Lee09a]. The enzyme from Campylobacter jejuni only produces carboxyspermidine in vivo even though it also can produce carboxynorspermidine in vitro [Hanfrey11].

Gene-Reaction Schematic: ?

Unification Links: KEGG:R09079 , Rhea:34114

Relationship Links: BRENDA:EC:1.5.1.43 , ENZYME:EC:1.5.1.43 , IUBMB-ExplorEnz:EC:1.5.1.43

Credits:
Created 04-Aug-2010 by Fulcher CA , SRI International
Revised 13-Aug-2012 by Caspi R , SRI International


References

Hanfrey11: Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ (2011). "Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota." J Biol Chem 286(50);43301-12. PMID: 22025614

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lee09a: Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ (2009). "An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae." J Biol Chem 284(15);9899-907. PMID: 19196710

Nakao91: Nakao H, Shinoda S, Yamamoto S (1991). "Purification and some properties of carboxynorspermidine synthase participating in a novel biosynthetic pathway for norspermidine in Vibrio alginolyticus." J Gen Microbiol 137(7);1737-42. PMID: 1955861


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 25, 2014, BIOCYC13A.