MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Aedes aegypti: fatty aldehyde dehydrogenase 3Inferred from experiment: ALDH3-2
Homo sapiens: fatty aldehyde dehydrogenaseInferred from experiment: ALDH3A2
Manduca sexta: farnesal dehydrogenaseInferred from experiment

In Pathway: juvenile hormone III biosynthesis I, juvenile hormone III biosynthesis II

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reactions:
an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+ (

an aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H + 2 H+ (

Enzyme Commission Primary Name: farnesal dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.105331Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Invoved in juvenile hormone production in insects. The enzyme was described from the corpora allata of Drosophila melanogaster (fruit fly), Manduca sexta (tobacco hornworm) and Aedes aegypti (yellow fever mosquito).

Citations: [Bede01, RiveraPerez13, Madhavan73, Baker83]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+] (
i1: (2E,6E)-farnesal + NAD+ + H2O → (2E,6E)-farnesoate + NADH + 2 H+ (

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 13-Aug-2010 by Dreher KA, TAIR


Baker83: Baker FC, Mauchamp B, Tsai LW, Schooley DA (1983). "Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta." J Lipid Res 24(12);1586-94. PMID: 6366103

Bede01: Bede JC, Teal PE, Goodman WG, Tobe SS (2001). "Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria." Plant Physiol 127(2);584-93. PMID: 11598232

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Madhavan73: Madhavan K, Conscience-Egli M, Sieber F, Ursprung H (1973). "Farnesol metabolism in Drosophila melanogaster: ontogeny and tissue distribution of octanol dehydrogenase and aldehyde oxidase." J Insect Physiol 19(1);235-41. PMID: 4631837

RiveraPerez13: Rivera-Perez C, Nouzova M, Clifton ME, Garcia EM, LeBlanc E, Noriega FG (2013). "Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes." Insect Biochem Mol Biol 43(8);675-82. PMID: 23639754

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Thu Nov 26, 2015, biocyc12.