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MetaCyc Reaction: 1.2.1.y

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.2.1.y

Enzymes and Genes:

Aedes aegypti : fatty aldehyde dehydrogenase 3 Inferred from experiment : ALDH3-2
Homo sapiens : fatty aldehyde dehydrogenase Inferred from experiment : ALDH3A2
Manduca sexta : farnesal dehydrogenase Inferred from experiment

In Pathway: juvenile hormone III biosynthesis I , juvenile hormone III biosynthesis II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reactions:
an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+ (1.2.1.3)

an aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H + 2 H+ (1.2.1.5)

Enzyme Commission Primary Name: farnesal dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.105331 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Invoved in juvenile hormone production in insects. The enzyme was described from the corpora allata of Drosophila melanogaster (fruit fly), Manduca sexta (tobacco hornworm) and Aedes aegypti (yellow fever mosquito).

Citations: [Bede01, RiveraPerez13, Madhavan73, Baker83]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+] (1.2.1.3):
i1: (2E,6E)-farnesal + NAD+ + H2O → (2E,6E)-farnesoate + NADH + 2 H+ (1.2.1.y)

Credits:
Created 13-Aug-2010 by Dreher KA , TAIR


References

Baker83: Baker FC, Mauchamp B, Tsai LW, Schooley DA (1983). "Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta." J Lipid Res 24(12);1586-94. PMID: 6366103

Bede01: Bede JC, Teal PE, Goodman WG, Tobe SS (2001). "Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria." Plant Physiol 127(2);584-93. PMID: 11598232

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Madhavan73: Madhavan K, Conscience-Egli M, Sieber F, Ursprung H (1973). "Farnesol metabolism in Drosophila melanogaster: ontogeny and tissue distribution of octanol dehydrogenase and aldehyde oxidase." J Insect Physiol 19(1);235-41. PMID: 4631837

RiveraPerez13: Rivera-Perez C, Nouzova M, Clifton ME, Garcia EM, LeBlanc E, Noriega FG (2013). "Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes." Insect Biochem Mol Biol 43(8);675-82. PMID: 23639754


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Thu Aug 27, 2015, biocyc13.