MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Corynebacterium glutamicum ATCC 13032 : acetaldehyde dehydrogenase : ald
Homo sapiens : 4-trimethylaminobutyraldehyde dehydrogenase : ALDH9A1
fatty aldehyde dehydrogenase : ALDH3A2
mitochondrial aldehyde dehydrogenase : ALDH2
Manduca sexta : farnesal dehydrogenase Inferred from experiment
Pseudomonas oleovorans : aldehyde dehydrogenase : alkH
Saccharomyces cerevisiae : aldehyde dehydrogenase : ALD3
aldehyde dehydrogenase : ALD2
potassium-activated aldehyde dehydrogenase, mitochondrial : ALD4
aldehyde dehydrogenase, mitochondrial : ALD5

In Pathway: juvenile hormone III biosynthesis I , juvenile hormone III biosynthesis II

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reactions:
an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+ (

an aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H + 2 H+ (

Enzyme Commission Primary Name: aldehyde dehydrogenase (NAD+)

Enzyme Commission Synonyms: CoA-independent aldehyde dehydrogenase, m-methylbenzaldehyde dehydrogenase, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, propionaldehyde dehydrogenase, aldehyde dehydrogenase (NAD)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.105331 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.

Citations: [Bede01, Racker49]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+] (
i1: (2E,6E)-farnesal + NAD+ + H2O → (2E,6E)-farnesoate + NADH + 2 H+ (

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Created 13-Aug-2010 by Dreher KA , TAIR


Bede01: Bede JC, Teal PE, Goodman WG, Tobe SS (2001). "Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria." Plant Physiol 127(2);584-93. PMID: 11598232

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Racker49: Racker, E. (1949). "Aldehyde dehydrogenase, a diphosphopyridine nucleotide-linked enzyme." J Biol Chem 177(2);883-92. PMID: 18110463

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sat May 30, 2015, BIOCYC13B.