|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 1.2.1.y
Enzymes and Genes:
|Aedes aegypti :||fatty aldehyde dehydrogenase 3
|Homo sapiens :||fatty aldehyde dehydrogenase
|Manduca sexta :||farnesal dehydrogenase
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: farnesal dehydrogenase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -13.105331 [Latendresse13]
Enzyme Commission Summary:
Invoved in juvenile hormone production in insects. The enzyme was described from the corpora allata of Drosophila melanogaster (fruit fly), Manduca sexta (tobacco hornworm) and Aedes aegypti (yellow fever mosquito).
Instance reaction of [an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+] (22.214.171.124):
i1: (2E,6E)-farnesal + NAD+ + H2O → (2E,6E)-farnesoate + NADH + 2 H+ (1.2.1.y)
Baker83: Baker FC, Mauchamp B, Tsai LW, Schooley DA (1983). "Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta." J Lipid Res 24(12);1586-94. PMID: 6366103
Bede01: Bede JC, Teal PE, Goodman WG, Tobe SS (2001). "Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria." Plant Physiol 127(2);584-93. PMID: 11598232
Madhavan73: Madhavan K, Conscience-Egli M, Sieber F, Ursprung H (1973). "Farnesol metabolism in Drosophila melanogaster: ontogeny and tissue distribution of octanol dehydrogenase and aldehyde oxidase." J Insect Physiol 19(1);235-41. PMID: 4631837
RiveraPerez13: Rivera-Perez C, Nouzova M, Clifton ME, Garcia EM, LeBlanc E, Noriega FG (2013). "Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes." Insect Biochem Mol Biol 43(8);675-82. PMID: 23639754
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