MetaCyc Reaction: 1.2.1.y

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

Enzymes and Genes:

Aedes aegypti : fatty aldehyde dehydrogenase 3 Inferred from experiment : ALDH3-2
Homo sapiens : fatty aldehyde dehydrogenase Inferred from experiment : ALDH3A2
Manduca sexta : farnesal dehydrogenase Inferred from experiment

In Pathway: juvenile hormone III biosynthesis I , juvenile hormone III biosynthesis II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reactions:
an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+ (

an aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H + 2 H+ (

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.105331 Inferred by computational analysis [Latendresse13]

Citations: [Bede01]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+] (
i1: (2E,6E)-farnesal + NAD+ + H2O → (2E,6E)-farnesoate + NADH + 2 H+ (1.2.1.y)

Created 13-Aug-2010 by Dreher KA , TAIR


Bede01: Bede JC, Teal PE, Goodman WG, Tobe SS (2001). "Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria." Plant Physiol 127(2);584-93. PMID: 11598232

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Oct 13, 2015, BIOCYC11A.