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MetaCyc Reaction: 3.4.24.80

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 3.4.24.80

Enzymes and Genes:

Homo sapiens : matrix metalloproteinase-14 Inferred from experiment : MMP14

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: membrane-type matrix metalloproteinase-1

Enzyme Commission Synonyms: matrix metalloproteinase 14

Taxonomic Range: Metazoa

Enzyme Commission Summary:
Endopeptidase activity. Activates procollagenase by cleavage of the propeptide at Asn37|Leu. Other bonds hydrolysed include Gly35|Ile in the propeptide of collagenase 3, and Asn341|Phe, Asp441|Leu and Gln354|Thr in the aggrecan interglobular domain.

In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.

Citations: [Itoh01]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:3.4.24.80 , ENZYME:EC:3.4.24.80 , IUBMB-ExplorEnz:EC:3.4.24.80

Credits:
Created 23-Sep-2010 by Caspi R , SRI International


References

Itoh01: Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M (2001). "Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion." EMBO J 20(17);4782-93. PMID: 11532942


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Aug 2, 2015, BIOCYC14B.