MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsProtein-Modification Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-ReactionsProtein-Modification Reactions

EC Number:

Enzymes and Genes:

Homo sapiens: matrix metalloproteinase-14Inferred from experiment: MMP14

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: membrane-type matrix metalloproteinase-1

Enzyme Commission Synonyms: matrix metalloproteinase 14

Taxonomic Range: Metazoa

Enzyme Commission Summary:
Endopeptidase activity. Activates procollagenase by cleavage of the propeptide at Asn37|Leu. Other bonds hydrolysed include Gly35|Ile in the propeptide of collagenase 3, and Asn341|Phe, Asp441|Leu and Gln354|Thr in the aggrecan interglobular domain.

In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.

Citations: [Itoh01]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 23-Sep-2010 by Caspi R, SRI International


Itoh01: Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M (2001). "Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion." EMBO J 20(17);4782-93. PMID: 11532942

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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