|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Protein-Modification Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions → Protein-Modification Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
|Homo sapiens :||matrix metalloproteinase-14
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Balance undetermined; a substrate lacks a chemical formula
Enzyme Commission Primary Name: membrane-type matrix metalloproteinase-1
Enzyme Commission Synonyms: matrix metalloproteinase 14
Taxonomic Range: Metazoa
Enzyme Commission Summary:
Endopeptidase activity. Activates procollagenase by cleavage of the propeptide at Asn37|Leu. Other bonds hydrolysed include Gly35|Ile in the propeptide of collagenase 3, and Asn341|Phe, Asp441|Leu and Gln354|Thr in the aggrecan interglobular domain.
In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.
Itoh01: Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M (2001). "Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion." EMBO J 20(17);4782-93. PMID: 11532942
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