|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 126.96.36.199
Enzymes and Genes:
|Corynebacterium glutamicum ATCC 13032:||acetaldehyde dehydrogenase: ald|
|Homo sapiens:||4-trimethylaminobutyraldehyde dehydrogenase: ALDH9A1|
fatty aldehyde dehydrogenase: ALDH3A2
mitochondrial aldehyde dehydrogenase: ALDH2
|Pseudomonas oleovorans:||aldehyde dehydrogenase: alkH|
|Saccharomyces cerevisiae:||aldehyde dehydrogenase: ALD3|
aldehyde dehydrogenase: ALD2
potassium-activated aldehyde dehydrogenase, mitochondrial: ALD4
aldehyde dehydrogenase, mitochondrial: ALD5
|Streptomyces cattleya:||fluoroacetaldehyde dehydrogenase|
In Pathway: fluoroacetate and fluorothreonine biosynthesis
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: fluoroacetaldehyde dehydrogenase
Enzyme Commission Synonyms: fluoroacetaldehyde:NAD+ oxidoreductase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -13.105316 [Latendresse13]
Enzyme Commission Summary:
The enzyme from Streptomyces cattleya has a high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde.
Instance reaction of [an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+] (188.8.131.52):
i1: fluoroacetaldehyde + NAD+ + H2O → fluoroacetate + NADH + 2 H+ (184.108.40.206)
Murphy01: Murphy CD, Moss SJ, O'Hagan D (2001). "Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya." Appl Environ Microbiol 67(10);4919-21. PMID: 11571203
Murphy03: Murphy CD, Schaffrath C, O'Hagan D (2003). "Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya." Chemosphere 52(2);455-61. PMID: 12738270
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