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MetaCyc Reaction: 1.2.1.69

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.2.1.69

Enzymes and Genes:

Corynebacterium glutamicum ATCC 13032 : acetaldehyde dehydrogenase : ald
Homo sapiens : 4-trimethylaminobutyraldehyde dehydrogenase : ALDH9A1
fatty aldehyde dehydrogenase : ALDH3A2
mitochondrial aldehyde dehydrogenase : ALDH2
Pseudomonas oleovorans : aldehyde dehydrogenase : alkH
Saccharomyces cerevisiae : aldehyde dehydrogenase : ALD3
aldehyde dehydrogenase : ALD2
potassium-activated aldehyde dehydrogenase, mitochondrial : ALD4
aldehyde dehydrogenase, mitochondrial : ALD5
Streptomyces cattleya : fluoroacetaldehyde dehydrogenase Inferred from experiment

In Pathway: fluoroacetate and fluorothreonine biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reactions:
an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+ (1.2.1.3)

an aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H + 2 H+ (1.2.1.5)

Enzyme Commission Primary Name: fluoroacetaldehyde dehydrogenase

Enzyme Commission Synonyms: fluoroacetaldehyde:NAD+ oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.105316 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme from Streptomyces cattleya has a high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde.

Citations: [Murphy01, Murphy03]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+] (1.2.1.3):
i1: fluoroacetaldehyde + NAD+ + H2O → fluoroacetate + NADH + 2 H+ (1.2.1.69)

Unification Links: KEGG:R07156 , Rhea:16680

Relationship Links: BRENDA:EC:1.2.1.69 , ENZYME:EC:1.2.1.69 , IUBMB-ExplorEnz:EC:1.2.1.69

Credits:
Created 06-Oct-2010 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Murphy01: Murphy CD, Moss SJ, O'Hagan D (2001). "Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya." Appl Environ Microbiol 67(10);4919-21. PMID: 11571203

Murphy03: Murphy CD, Schaffrath C, O'Hagan D (2003). "Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya." Chemosphere 52(2);455-61. PMID: 12738270


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri May 29, 2015, BIOCYC13B.