Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.2.1.69

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.2.1.69

Enzymes and Genes:
fluoroacetaldehyde dehydrogenase Inferred from experiment ( Streptomyces cattleya )
aldehyde dehydrogenase : alkH ( Pseudomonas oleovorans )
mitochondrial aldehyde dehydrogenase : ALDH2 ( Homo sapiens )
aldehyde dehydrogenase, mitochondrial : ALD5 ( Saccharomyces cerevisiae )
potassium-activated aldehyde dehydrogenase, mitochondrial : ALD4 ( Saccharomyces cerevisiae )
aldehyde dehydrogenase : ALD2 ( Saccharomyces cerevisiae )
aldehyde dehydrogenase : ALD3 ( Saccharomyces cerevisiae )
fatty aldehyde dehydrogenase : ALDH3A2 ( Homo sapiens )
4-trimethylaminobutyraldehyde dehydrogenase : ALDH9A1 ( Homo sapiens )

In Pathway: fluoroacetate and fluorothreonine biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reactions:
an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+ (1.2.1.3)

an aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H + 2 H+ (1.2.1.5)

Enzyme Commission Primary Name: fluoroacetaldehyde dehydrogenase

Enzyme Commission Synonyms: fluoroacetaldehyde:NAD+ oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.105316 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme from Streptomyces cattleya has a high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde.

Citations: [Murphy01, Murphy03]

Gene-Reaction Schematic: ?

Instance reaction of [an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+] (1.2.1.3):
i1: fluoroacetaldehyde + NAD+ + H2O → fluoroacetate + NADH + 2 H+ (1.2.1.69)

Unification Links: KEGG:R07156 , Rhea:16680

Relationship Links: BRENDA:EC:1.2.1.69 , ENZYME:EC:1.2.1.69 , IUBMB-ExplorEnz:EC:1.2.1.69

Credits:
Created 06-Oct-2010 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Murphy01: Murphy CD, Moss SJ, O'Hagan D (2001). "Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya." Appl Environ Microbiol 67(10);4919-21. PMID: 11571203

Murphy03: Murphy CD, Schaffrath C, O'Hagan D (2003). "Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya." Chemosphere 52(2);455-61. PMID: 12738270


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, BIOCYC14B.