|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
Enzymes and Genes:
fluoroacetaldehyde dehydrogenase ( Streptomyces cattleya )
aldehyde dehydrogenase : alkH ( Pseudomonas oleovorans )
mitochondrial aldehyde dehydrogenase : ALDH2 ( Homo sapiens )
aldehyde dehydrogenase, mitochondrial : ALD5 ( Saccharomyces cerevisiae )
potassium-activated aldehyde dehydrogenase, mitochondrial : ALD4 ( Saccharomyces cerevisiae )
aldehyde dehydrogenase : ALD2 ( Saccharomyces cerevisiae )
aldehyde dehydrogenase : ALD3 ( Saccharomyces cerevisiae )
fatty aldehyde dehydrogenase : ALDH3A2 ( Homo sapiens )
4-trimethylaminobutyraldehyde dehydrogenase : ALDH9A1 ( Homo sapiens )
In Pathway: fluoroacetate and fluorothreonine biosynthesis
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: fluoroacetaldehyde dehydrogenase
Enzyme Commission Synonyms: fluoroacetaldehyde:NAD+ oxidoreductase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -13.105316 [Latendresse, 2013]
Enzyme Commission Summary:
The enzyme from Streptomyces cattleya has a high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde.
Instance reaction of [an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+] (184.108.40.206):
i1: fluoroacetaldehyde + NAD+ + H2O → fluoroacetate + NADH + 2 H+ (220.127.116.11)
Murphy01a: Murphy CD, Moss SJ, O'Hagan D (2001). "Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya." Appl Environ Microbiol 67(10);4919-21. PMID: 11571203
Murphy03: Murphy CD, Schaffrath C, O'Hagan D (2003). "Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya." Chemosphere 52(2);455-61. PMID: 12738270
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