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MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Corynebacterium glutamicum ATCC 13032: acetaldehyde dehydrogenase: ald
Homo sapiens: 4-trimethylaminobutyraldehyde dehydrogenase: ALDH9A1
fatty aldehyde dehydrogenase: ALDH3A2
mitochondrial aldehyde dehydrogenase: ALDH2
Pseudomonas oleovorans: aldehyde dehydrogenase: alkH
Saccharomyces cerevisiae: aldehyde dehydrogenase: ALD3
aldehyde dehydrogenase: ALD2
potassium-activated aldehyde dehydrogenase, mitochondrial: ALD4
aldehyde dehydrogenase, mitochondrial: ALD5
Streptomyces cattleya: fluoroacetaldehyde dehydrogenaseInferred from experiment

In Pathway: fluoroacetate and fluorothreonine biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reactions:
an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+ (

an aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H + 2 H+ (

Enzyme Commission Primary Name: fluoroacetaldehyde dehydrogenase

Enzyme Commission Synonyms: fluoroacetaldehyde:NAD+ oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.105316Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme from Streptomyces cattleya has a high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde.

Citations: [Murphy01a, Murphy03]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R07156, Rhea:16680

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 06-Oct-2010 by Caspi R, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Murphy01a: Murphy CD, Moss SJ, O'Hagan D (2001). "Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya." Appl Environ Microbiol 67(10);4919-21. PMID: 11571203

Murphy03: Murphy CD, Schaffrath C, O'Hagan D (2003). "Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya." Chemosphere 52(2);455-61. PMID: 12738270

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Thu Apr 28, 2016, biocyc13.