MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Scutellaria baicalensis: baicalin-β-D-glucuronidaseInferred from experiment: SGUS
Scutellaria viscidula: baicalin β-D-glucuronidaseInferred from experiment

In Pathway: baicalein degradation (hydrogen peroxide detoxification), baicalein metabolism

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: baicalin-β-D-glucuronidase

Enzyme Commission Synonyms: baicalinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -3.1129913Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme also hydrolyses wogonin 7-O-β-D-glucuronide and oroxylin 7-O-β-D-glucuronide with lower efficiency [Morimoto95]. Neglegible activity with p-nitrophenyl-β-D-glucuronide [Zhang05].

Citations: [Ikegami95, Sasaki00]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: Rhea:28130

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 11-Oct-2010 by Caspi R, SRI International


Ikegami95: Ikegami F, Matsunae K, Hisamitsu M, Kurihara T, Yamamoto T, Murakoshi I (1995). "Purification and properties of a plant beta-D-glucuronidase form Scutellaria root." Biol Pharm Bull 18(11);1531-4. PMID: 8593473

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Morimoto95: Morimoto, S., Harioka, T., Shoyama, Y. (1995). "Purification and characterization of flavone-specific β-glucuronidase from callus cultures of Scutellaria baicalensis Georgi." Planta 195:535-540.

Sasaki00: Sasaki K, Taura F, Shoyama Y, Morimoto S (2000). "Molecular characterization of a novel beta-glucuronidase from Scutellaria baicalensis georgi." J Biol Chem 275(35);27466-72. PMID: 10858442

Zhang05: Zhang, C., Hang, Y., Chen, J., Liang, X. (2005). "Purification and characterization of baicalin-β-D-glucuronidase hydrolyzing baicalin to baicalein from fresh roots of Scutellaria viscidula Bge." Proc. Biochem. 40:1911-1915.

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Thu Nov 26, 2015, BIOCYC14B.