MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Scutellaria baicalensis : baicalin-β-D-glucuronidase Inferred from experiment : SGUS
Scutellaria viscidula : baicalin β-D-glucuronidase Inferred from experiment

In Pathway: baicalein degradation (hydrogen peroxide detoxification) , baicalein metabolism

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: baicalin-β-D-glucuronidase

Enzyme Commission Synonyms: baicalinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -3.1129913 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme also hydrolyses wogonin 7-O-β-D-glucuronide and oroxylin 7-O-β-D-glucuronide with lower efficiency [Morimoto95]. Neglegible activity with p-nitrophenyl-β-D-glucuronide [Zhang05b].

Citations: [Ikegami95, Sasaki00]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: Rhea:28130

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Created 11-Oct-2010 by Caspi R , SRI International


Ikegami95: Ikegami F, Matsunae K, Hisamitsu M, Kurihara T, Yamamoto T, Murakoshi I (1995). "Purification and properties of a plant beta-D-glucuronidase form Scutellaria root." Biol Pharm Bull 18(11);1531-4. PMID: 8593473

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Morimoto95: Morimoto, S., Harioka, T., Shoyama, Y. (1995). "Purification and characterization of flavone-specific β-glucuronidase from callus cultures of Scutellaria baicalensis Georgi." Planta 195:535-540.

Sasaki00: Sasaki K, Taura F, Shoyama Y, Morimoto S (2000). "Molecular characterization of a novel beta-glucuronidase from Scutellaria baicalensis georgi." J Biol Chem 275(35);27466-72. PMID: 10858442

Zhang05b: Zhang, C., Hang, Y., Chen, J., Liang, X. (2005). "Purification and characterization of baicalin-β-D-glucuronidase hydrolyzing baicalin to baicalein from fresh roots of Scutellaria viscidula Bge." Proc. Biochem. 40:1911-1915.

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Aug 3, 2015, BIOCYC14B.