|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: baicalin-β-D-glucuronidase
Enzyme Commission Synonyms: baicalinase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -3.1129913 [Latendresse13]
Enzyme Commission Summary:
The enzyme also hydrolyses wogonin 7-O-β-D-glucuronide and oroxylin 7-O-β-D-glucuronide with lower efficiency [Morimoto95]. Neglegible activity with p-nitrophenyl-β-D-glucuronide [Zhang05c].
Unification Links: Rhea:28130
Ikegami95: Ikegami F, Matsunae K, Hisamitsu M, Kurihara T, Yamamoto T, Murakoshi I (1995). "Purification and properties of a plant beta-D-glucuronidase form Scutellaria root." Biol Pharm Bull 18(11);1531-4. PMID: 8593473
Morimoto95: Morimoto, S., Harioka, T., Shoyama, Y. (1995). "Purification and characterization of flavone-specific β-glucuronidase from callus cultures of Scutellaria baicalensis Georgi." Planta 195:535-540.
Sasaki00a: Sasaki K, Taura F, Shoyama Y, Morimoto S (2000). "Molecular characterization of a novel beta-glucuronidase from Scutellaria baicalensis georgi." J Biol Chem 275(35);27466-72. PMID: 10858442
Zhang05c: Zhang, C., Hang, Y., Chen, J., Liang, X. (2005). "Purification and characterization of baicalin-β-D-glucuronidase hydrolyzing baicalin to baicalein from fresh roots of Scutellaria viscidula Bge." Proc. Biochem. 40:1911-1915.
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