Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 6.3.2.36

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 6.3.2.36

Enzymes and Genes:
4-phosphopantoate-β-alanine ligase Inferred from experiment : TK1686 ( Thermococcus kodakarensis )

In Pathway: phosphopantothenate biosynthesis III

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 4-phosphopantoate—β-alanine ligase

Enzyme Commission Synonyms: phosphopantothenate synθse, TK1686 protein

Standard Gibbs Free Energy (ΔrG in kcal/mol): -18.625854 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with β-alanine, followed by phosphrylation (EC 6.3.2.1 and EC 2.7.1.33, respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with β-alanine. The two archaeal enzymes that catalyse this conversion are EC 2.7.1.169, pantoate kinase, and this enzyme.

Citations: [Yokooji09]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R09379 , Rhea:27930

Relationship Links: BRENDA:EC:6.3.2.36 , ENZYME:EC:6.3.2.36 , IUBMB-ExplorEnz:EC:6.3.2.36

Credits:
Created 21-Oct-2010 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Yokooji09: Yokooji Y, Tomita H, Atomi H, Imanaka T (2009). "Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea." J Biol Chem 284(41);28137-45. PMID: 19666462


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC13B.