MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Thermococcus kodakarensis: 4-phosphopantoate-β-alanine ligaseInferred from experiment: TK1686

In Pathway: phosphopantothenate biosynthesis III

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 4-phosphopantoate—β-alanine ligase

Enzyme Commission Synonyms: phosphopantothenate synthetase, TK1686 protein

Standard Gibbs Free Energy (ΔrG in kcal/mol): -18.625854Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with β-alanine, followed by phosphrylation ( EC and EC, respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with β-alanine. The two archaeal enzymes that catalyse this conversion are EC, pantoate kinase, and this enzyme.

Citations: [Yokooji09]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R09379, Rhea:27930

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 21-Oct-2010 by Caspi R, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Yokooji09: Yokooji Y, Tomita H, Atomi H, Imanaka T (2009). "Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea." J Biol Chem 284(41);28137-45. PMID: 19666462

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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