MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Thermococcus kodakarensis : 4-phosphopantoate-β-alanine ligase Inferred from experiment : TK1686

In Pathway: phosphopantothenate biosynthesis III

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 4-phosphopantoate—β-alanine ligase

Enzyme Commission Synonyms: phosphopantothenate synθse, TK1686 protein

Standard Gibbs Free Energy (ΔrG in kcal/mol): -18.625854 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with β-alanine, followed by phosphrylation (EC and EC, respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with β-alanine. The two archaeal enzymes that catalyse this conversion are EC, pantoate kinase, and this enzyme.

Citations: [Yokooji09]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R09379 , Rhea:27930

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Created 21-Oct-2010 by Caspi R , SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Yokooji09: Yokooji Y, Tomita H, Atomi H, Imanaka T (2009). "Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea." J Biol Chem 284(41);28137-45. PMID: 19666462

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Oct 4, 2015, biocyc14.