|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
Enzymes and Genes:
|Thermococcus kodakarensis:||4-phosphopantoate-β-alanine ligase: TK1686|
In Pathway: phosphopantothenate biosynthesis III
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 4-phosphopantoate—β-alanine ligase
Enzyme Commission Synonyms: phosphopantothenate synthetase, TK1686 protein
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -18.625854 [Latendresse13]
Enzyme Commission Summary:
The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with β-alanine, followed by phosphrylation ( EC 184.108.40.206 and EC 220.127.116.11, respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with β-alanine. The two archaeal enzymes that catalyse this conversion are EC 18.104.22.168, pantoate kinase, and this enzyme.
Yokooji09: Yokooji Y, Tomita H, Atomi H, Imanaka T (2009). "Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea." J Biol Chem 284(41);28137-45. PMID: 19666462
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