|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Marked as unbalanced.
Enzyme Commission Primary Name: isoflavone 2′-hydroxylase
Enzyme Commission Synonyms: isoflavone 2'-monooxygenase, CYP81E1, CYP Ge-3
Taxonomic Range: Viridiplantae
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -93.92053 [Latendresse13]
Enzyme Commission Summary:
A heme-thiolate protein (P-450). Acts on daidzein, formononetin and genistein. EC 184.108.40.206, 4'-methoxyisoflavone 2'-hydroxylase, has the same reaction but is more specific as it requires a 4'-methoxyisoflavone.
Akashi98: Akashi T, Aoki T, Ayabe S (1998). "CYP81E1, a cytochrome P450 cDNA of licorice (Glycyrrhiza echinata L.), encodes isoflavone 2'-hydroxylase." Biochem Biophys Res Commun 251(1);67-70. PMID: 9790908
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