MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: isoflavone 2′-hydroxylase

Enzyme Commission Synonyms: isoflavone 2'-monooxygenase, CYP81E1, CYP Ge-3

Taxonomic Range: Viridiplantae

Standard Gibbs Free Energy (ΔrG in kcal/mol): -93.92053Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A heme-thiolate protein (P-450). Acts on daidzein, formononetin and genistein. EC, 4'-methoxyisoflavone 2'-hydroxylase, has the same reaction but is more specific as it requires a 4'-methoxyisoflavone.

Citations: [Akashi98]

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 09-Nov-2010 by Caspi R, SRI International


Akashi98: Akashi T, Aoki T, Ayabe S (1998). "CYP81E1, a cytochrome P450 cDNA of licorice (Glycyrrhiza echinata L.), encodes isoflavone 2'-hydroxylase." Biochem Biophys Res Commun 251(1);67-70. PMID: 9790908

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Mon Nov 30, 2015, biocyc13.