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MetaCyc Reaction: 2.7.7.74

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.7.74

Enzymes and Genes:

Archaeoglobus fulgidus : bifubnctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase Inferred from experiment : ipct/dipps

In Pathway: di-myo-inositol phosphate biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1L-myo-inositol 1-phosphate cytidylyltransferase

Enzyme Commission Synonyms: CTP:inositol-1-phosphate cytidylyltransferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS)), IPCT (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS)), L-myo-inositol-1-phosphate cytidylyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -103.30353 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
In many organisms this activity is catalyzed by a bifunctional enzyme. The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments.

Citations: [Rodrigues07]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: Rhea:30650

Relationship Links: BRENDA:EC:2.7.7.74 , ENZYME:EC:2.7.7.74 , IUBMB-ExplorEnz:EC:2.7.7.74

Credits:
Created 29-Nov-2010 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Rodrigues07: Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H (2007). "Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles." J Bacteriol 189(15);5405-12. PMID: 17526717


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Jul 3, 2015, biocyc11.