Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.5.3.17

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.5.3.17

Enzymes and Genes:
non-specific polyamine oxidase Inferred from experiment : PAO3 ( Arabidopsis thaliana col )

In Pathway: spermine and spermidine degradation III

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: non-specific polyamine oxidase

Enzyme Commission Synonyms: polyamine oxidase (ambiguous), Fms1, AtPAO3

Standard Gibbs Free Energy (ΔrG in kcal/mol): -22.204742 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A flavoprotein (FAD). The non-specific polyamine oxidases may differ from each other considerably. The enzyme from Saccharomyces cerevisiae shows a rather broad specificity and also oxidizes N8-acetylspermidine [Landry03]. The enzyme from Ascaris suum shows high activity with spermine and spermidine, but also oxidizes norspermine [Muller92a]. The enzyme from Arabidopsis thaliana shows high activity with spermidine, but also oxidizes other polyamines [Moschou08]. The specific polyamine oxidases are classified as EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming)) and EC 1.5.3.16 (spermine oxidase).

Citations: [Wang01f]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R09077 , Rhea:25808

Relationship Links: BRENDA:EC:1.5.3.17 , ENZYME:EC:1.5.3.17 , IUBMB-ExplorEnz:EC:1.5.3.17

Credits:
Created 24-Jan-2011 by Caspi R , SRI International


References

Landry03: Landry J, Sternglanz R (2003). "Yeast Fms1 is a FAD-utilizing polyamine oxidase." Biochem Biophys Res Commun 303(3);771-6. PMID: 12670477

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Moschou08: Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA (2008). "Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis." Plant Physiol 147(4);1845-57. PMID: 18583528

Muller92a: Muller S, Walter RD (1992). "Purification and characterization of polyamine oxidase from Ascaris suum." Biochem J 283 ( Pt 1);75-80. PMID: 1567380

Wang01f: Wang Y, Devereux W, Woster PM, Stewart TM, Hacker A, Casero RA (2001). "Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure." Cancer Res 61(14);5370-3. PMID: 11454677


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc13.