|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 184.108.40.206
Enzymes and Genes:
|Arabidopsis thaliana col:||non-specific polyamine oxidase: PAO3|
In Pathway: spermine and spermidine degradation III
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
Enzyme Commission Primary Name: non-specific polyamine oxidase
Enzyme Commission Synonyms: polyamine oxidase (ambiguous), Fms1, AtPAO3
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -22.204742 [Latendresse13]
Enzyme Commission Summary:
A flavoprotein (FAD). The non-specific polyamine oxidases may differ from each other considerably. The enzyme from Saccharomyces cerevisiae shows a rather broad specificity and also oxidizes N8-acetylspermidine [Landry03]. The enzyme from Ascaris suum shows high activity with spermine and spermidine, but also oxidizes norspermine [Muller92a]. The enzyme from Arabidopsis thaliana shows high activity with spermidine, but also oxidizes other polyamines [Moschou08]. The specific polyamine oxidases are classified as EC 220.127.116.11 (N1-acetylpolyamine oxidase), EC 18.104.22.168 (polyamine oxidase (propane-1,3-diamine-forming)), EC 22.214.171.124 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming)) and EC 126.96.36.199 (spermine oxidase).
Moschou08: Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA (2008). "Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis." Plant Physiol 147(4);1845-57. PMID: 18583528
Wang01b: Wang Y, Devereux W, Woster PM, Stewart TM, Hacker A, Casero RA (2001). "Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure." Cancer Res 61(14);5370-3. PMID: 11454677
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