|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
In Pathway: spermine and spermidine degradation III
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: non-specific polyamine oxidase
Enzyme Commission Synonyms: polyamine oxidase (ambiguous), Fms1, AtPAO3
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -22.204742 [Latendresse13]
Enzyme Commission Summary:
A flavoprotein (FAD). The non-specific polyamine oxidases may differ from each other considerably. The enzyme from Saccharomyces cerevisiae shows a rather broad specificity and also oxidizes N8-acetylspermidine [Landry03]. The enzyme from Ascaris suum shows high activity with spermine and spermidine, but also oxidizes norspermine [Muller92]. The enzyme from Arabidopsis thaliana shows high activity with spermidine, but also oxidizes other polyamines [Moschou08]. The specific polyamine oxidases are classified as EC 184.108.40.206 (N1-acetylpolyamine oxidase), EC 220.127.116.11 (polyamine oxidase (propane-1,3-diamine-forming)), EC 18.104.22.168 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming)) and EC 22.214.171.124 (spermine oxidase).
Moschou08: Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA (2008). "Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis." Plant Physiol 147(4);1845-57. PMID: 18583528
Wang01a: Wang Y, Devereux W, Woster PM, Stewart TM, Hacker A, Casero RA (2001). "Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure." Cancer Res 61(14);5370-3. PMID: 11454677
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