Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.11.1.21

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.11.1.21

Enzymes and Genes:
hydroperoxidase I Inferred from experiment : katG ( Escherichia coli K-12 substr. MG1655 )
versatile peroxidase VPL1 Inferred from experiment : vpl1 ( Pleurotus eryngii )
versatile peroxidase VPL2 Inferred from experiment : vpl2 ( Pleurotus eryngii )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: catalase-peroxidase

Enzyme Commission Synonyms: katG (gene name)

Enzyme Commission Summary:
Differs from EC 1.11.1.7, peroxidase in having a relatively high catalase (EC 1.11.1.6) activity with hydrogen peroxide as donor, releasing oxygen; both activities use the same heme active site. In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.

Citations: [Loewen85, Hochman91, Fraaije96, Bertrand04, Vlasits10]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R03532

Relationship Links: BRENDA:EC:1.11.1.21 , ENZYME:EC:1.11.1.21 , IUBMB-ExplorEnz:EC:1.11.1.21

Credits:
Revised 13-Sep-2012 by Caspi R , SRI International


References

Bertrand04: Bertrand T, Eady NA, Jones JN, Jesmin , Nagy JM, Jamart-Gregoire B, Raven EL, Brown KA (2004). "Crystal structure of Mycobacterium tuberculosis catalase-peroxidase." J Biol Chem 279(37);38991-9. PMID: 15231843

Fraaije96: Fraaije MW, Roubroeks HP, Hagen WR, Van Berkel WJ (1996). "Purification and characterization of an intracellular catalase-peroxidase from Penicillium simplicissimum." Eur J Biochem 235(1-2);192-8. PMID: 8631329

Hochman91: Hochman A, Goldberg I (1991). "Purification and characterization of a catalase-peroxidase and a typical catalase from the bacterium Klebsiella pneumoniae." Biochim Biophys Acta 1077(3);299-307. PMID: 2029529

Loewen85: Loewen PC, Triggs BL, George CS, Hrabarchuk BE (1985). "Genetic mapping of katG, a locus that affects synthesis of the bifunctional catalase-peroxidase hydroperoxidase I in Escherichia coli." J Bacteriol 1985;162(2);661-7. PMID: 3886630

Vlasits10: Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C (2010). "Mechanisms of catalase activity of heme peroxidases." Arch Biochem Biophys 500(1);74-81. PMID: 20434429


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc13.