MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: 3β-hydroxy sterol glucosyltransferaseInferred from experiment: UGT80A2
Withania somnifera: 3β-hydroxy sterol glucosyltransferaseInferred from experiment: SGTL1

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: sterol 3β-glucosyltransferase

Enzyme Commission Synonyms: UDPG:sterol glucosyltransferase, UDP-glucose-sterol β-glucosyltransferase, sterol:UDPG glucosyltransferase, UDPG-SGTase, uridine diphosphoglucose-poriferasterol glucosyltransferase, uridine diphosphoglucose-sterol glucosyltransferase, sterol glucosyltransferase, sterol-β-D-glucosyltransferase, UDP-glucose-sterol glucosyltransferase

Taxonomic Range: Viridiplantae, Fungi

Standard Gibbs Free Energy (ΔrG in kcal/mol): 6.8975983Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Not identical with EC (nuatigenin 3β-glucosyltransferase) or EC (sarsapogenin 3β-glucosyltransferase).

Citations: [Sharma07, MurakamiMurofus89]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [UDP-α-D-glucose + a sterol = UDP + a sterol 3-β-D-glucoside + H+] (
i1: UDP-α-D-glucose + ergosterol = ergosterol 3-O-β-D-glucoside + UDP + H+ (

i2: UDP-α-D-glucose + cholesterol = UDP + cholesteryl-β-D-glucoside + H+ (

i3: UDP-α-D-glucose + solasodine = UDP + solasodine 3-O-β-D-glucoside + H+ (

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 04-Feb-2011 by Dreher KA, TAIR


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

MurakamiMurofus89: Murakami-Murofushi K, Ohta J (1989). "Expression of UDP-glucose: poriferasterol glucosyltransferase in the process of differentiation of a true slime mold, Physarum polycephalum." Biochim Biophys Acta 992(3);412-5. PMID: 2528379

Sharma07: Sharma LK, Madina BR, Chaturvedi P, Sangwan RS, Tuli R (2007). "Molecular cloning and characterization of one member of 3beta-hydroxy sterol glucosyltransferase gene family in Withania somnifera." Arch Biochem Biophys 460(1);48-55. PMID: 17324374

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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