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MetaCyc Reaction: 1.2.1.-

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.2.1.-

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655 : NADPH-dependent aldehyde reductase : yqhD
Saccharomyces cerevisiae : potassium-activated aldehyde dehydrogenase, mitochondrial : ALD4
aldehyde dehydrogenase, mitochondrial : ALD5
Scheffersomyces stipitis CBS 6054 : NAD(P)+ L-lactaldehyde dehydrogenase Inferred from experiment : LADH

In Pathway: L-rhamnose degradation II

Reaction Locations: cytosol

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1.2.1 -- With NAD(+) or NADP(+) as acceptor

Standard Gibbs Free Energy (ΔrG in kcal/mol): -14.78363 Inferred by computational analysis [Latendresse13]

Citations: [Watanabe08]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [an aldehyde + NADP+ + H2O → a carboxylate + NADPH + 2 H+] (1.2.1.4):
i1: (S)-lactaldehyde + NADP+ + H2O → (S)-lactate + NADPH + 2 H+ (1.2.1.-)

Credits:
Created 16-Feb-2011 by Fulcher CA , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Watanabe08: Watanabe S, Piyanart S, Makino K (2008). "Metabolic fate of L-lactaldehyde derived from an alternative L-rhamnose pathway." FEBS J 275(20);5139-49. PMID: 18793327


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Wed Sep 2, 2015, biocyc11.