Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.6.1.6

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.6.1.6

Enzymes and Genes:
nucleoside diphosphate phosphatase Inferred from experiment ( Allium cepa )
nucleoside triphosphate phosphohydrolase : ytkD ( Bacillus subtilis subtilis 168 )
apyrase : YND1 ( Saccharomyces cerevisiae )
apyrase ( Pisum sativum )
ectonucleoside triphosphate diphosphohydrolase 4 : ENTPD4 ( Homo sapiens )

Sub-reaction of:
3.6.1.5: CTP + 2 H2O → CMP + 2 phosphate + 2 H+

In Pathway: UTP and CTP dephosphorylation I

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: nucleoside diphosphate phosphatase

Enzyme Commission Synonyms: nucleoside-diphosphatase, thiaminpyrophosphatase, UDPase, inosine diphosphatase, adenosine diphosphatase, IDPase, ADPase, adenosinepyrophosphatase, guanosine diphosphatase, guanosine 5'-diphosphatase, inosine 5'-diphosphatase, uridine diphosphatase, uridine 5'-diphosphatase, type B nucleoside diphosphatase, GDPase, CDPase, nucleoside 5'-diphosphatase, type L nucleoside diphosphatase, NDPase, nucleoside diphosphate phosphohydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -6.8129883 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on IDP, GDP, UDP and also on D-ribose 5-diphosphate, but not on ADP.

Citations: [Uccelletti04, Failer02, Yeung00, Gibson55]

Gene-Reaction Schematic: ?

Instance reaction of [a nucleoside diphosphate + H2O = a nucleoside 5'-monophosphate + phosphate + H+] (3.6.1.6):
i1: CDP + H2O → CMP + phosphate + H+ (3.6.1.6)

Unification Links: KEGG:R00514

Relationship Links: BRENDA:EC:3.6.1.6 , ENZYME:EC:3.6.1.6 , IUBMB-ExplorEnz:EC:3.6.1.6

Credits:
Created 28-Feb-2011 by Zhang P , TAIR


References

Failer02: Failer BU, Braun N, Zimmermann H (2002). "Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase." J Biol Chem 277(40);36978-86. PMID: 12167635

Gibson55: Gibson DM, Ayengar P, Sanadi DR (1955). "A phosphatase specific for nucleoside diphosphates." Biochim Biophys Acta 16(4);536-8. PMID: 14389272

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Uccelletti04: Uccelletti D, O'Callaghan C, Berninsone P, Zemtseva I, Abeijon C, Hirschberg CB (2004). "ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans." J Biol Chem 279(26);27390-8. PMID: 15102851

Yeung00: Yeung G, Mulero JJ, McGowan DW, Bajwa SS, Ford JE (2000). "CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart." Biochemistry 39(42);12916-23. PMID: 11041856


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Dec 17, 2014, BIOCYC13A.