Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: [no EC number assigned]

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

Sub-reaction of:
2.5.1.99: 2 geranylgeranyl diphosphate = all-trans-phytoene + 2 diphosphate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Standard Gibbs Free Energy (ΔrG in kcal/mol): -3.6599884 Inferred by computational analysis [Latendresse13]

Summary:
Requires Mn2+ for activity. The enzyme appears to be stereospecific, normally producing 15-cis-phytoene. However, in Pantoea agglomerans (Erwinia herbicola), the product is the 15-trans isomer [IwataReuyl03].

Citations: [Gregonis74, Misawa94]

Credits:
Created 17-Mar-2011 by Caspi R , SRI International


References

Gregonis74: Gregonis DE, Rilling HC (1974). "The stereochemistry of trans-phytoene synthesis. Some observations on lycopersene as a carotene precursor and a mechanism for the synthesis of cis- and trans-phytoene." Biochemistry 13(7);1538-42. PMID: 4819767

IwataReuyl03: Iwata-Reuyl D, Math SK, Desai SB, Poulter CD (2003). "Bacterial phytoene synthase: molecular cloning, expression, and characterization of Erwinia herbicola phytoene synthase." Biochemistry 42(11);3359-65. PMID: 12641468

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Misawa94: Misawa N, Truesdale MR, Sandmann G, Fraser PD, Bird C, Schuch W, Bramley PM (1994). "Expression of a tomato cDNA coding for phytoene synthase in Escherichia coli, phytoene formation in vivo and in vitro, and functional analysis of the various truncated gene products." J Biochem 116(5);980-5. PMID: 7896759


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC13B.