|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: sphingomyelin deacylase
Enzyme Commission Synonyms: SM deacylase, GcSM deacylase, glucosylceramide sphingomyelin deacylase, sphingomyelin glucosylceramide deacylase, SM glucosylceramide GCer deacylase, SM-GCer deacylase, SMGCer deacylase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 471.3844 [Latendresse13]
Enzyme Commission Summary:
The enzyme is involved in the sphingolipid metabolism in the epidermis.
Unification Links: Rhea:30918
Hara00: Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G (2000). "High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis." J Invest Dermatol 115(3);406-13. PMID: 10951276
Higuchi00: Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G (2000). "The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide." Biochem J 350 Pt 3;747-56. PMID: 10970788
Ishibashi03: Ishibashi M, Arikawa J, Okamoto R, Kawashima M, Takagi Y, Ohguchi K, Imokawa G (2003). "Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis." Lab Invest 83(3);397-408. PMID: 12649340
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