MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Homo sapiens : sphingomyelin deacylase Inferred from experiment

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: sphingomyelin deacylase

Enzyme Commission Synonyms: SM deacylase, GcSM deacylase, glucosylceramide sphingomyelin deacylase, sphingomyelin glucosylceramide deacylase, SM glucosylceramide GCer deacylase, SM-GCer deacylase, SMGCer deacylase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 471.3844 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme is involved in the sphingolipid metabolism in the epidermis.

Citations: [Hara00, Higuchi00, Ishibashi03]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: Rhea:30918

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Created 13-Apr-2011 by Caspi R , SRI International


Hara00: Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G (2000). "High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis." J Invest Dermatol 115(3);406-13. PMID: 10951276

Higuchi00: Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G (2000). "The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide." Biochem J 350 Pt 3;747-56. PMID: 10970788

Ishibashi03: Ishibashi M, Arikawa J, Okamoto R, Kawashima M, Takagi Y, Ohguchi K, Imokawa G (2003). "Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis." Lab Invest 83(3);397-408. PMID: 12649340

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Oct 9, 2015, BIOCYC11A.