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MetaCyc Reaction: 3.5.1.109

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 3.5.1.109

Enzymes and Genes:

Homo sapiens: sphingomyelin deacylaseInferred from experiment

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: sphingomyelin deacylase

Enzyme Commission Synonyms: SM deacylase, GcSM deacylase, glucosylceramide sphingomyelin deacylase, sphingomyelin glucosylceramide deacylase, SM glucosylceramide GCer deacylase, SM-GCer deacylase, SMGCer deacylase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 471.3844Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme is involved in the sphingolipid metabolism in the epidermis.

Citations: [Hara00, Higuchi00, Ishibashi03]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: Rhea:30918

Relationship Links: BRENDA:EC:3.5.1.109, ENZYME:EC:3.5.1.109, IUBMB-ExplorEnz:EC:3.5.1.109

Credits:
Created 13-Apr-2011 by Caspi R, SRI International


References

Hara00: Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G (2000). "High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis." J Invest Dermatol 115(3);406-13. PMID: 10951276

Higuchi00: Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G (2000). "The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide." Biochem J 350 Pt 3;747-56. PMID: 10970788

Ishibashi03: Ishibashi M, Arikawa J, Okamoto R, Kawashima M, Takagi Y, Ohguchi K, Imokawa G (2003). "Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis." Lab Invest 83(3);397-408. PMID: 12649340

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed May 4, 2016, biocyc14.