|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Polynucleotide-Reactions → RNA-Reactions → tRNA-Reactions|
EC Number: 22.214.171.124
Enzymes and Genes:
|Saccharomyces cerevisiae:||tRNASer (uridine44-2′-O)-methyltransferase: TRM44|
In Pathway: tRNA methylation (yeast)
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: tRNASer (uridine44-2′-O)-methyltransferase
Enzyme Commission Synonyms: TRM44
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -24.902222 [Latendresse13]
Enzyme Commission Summary:
The 2'-O-methylation of uridine44 contributes to stability of tRNASer(CGA).
Citations: [Kotelawala08 ]
Kotelawala08: Kotelawala L, Grayhack EJ, Phizicky EM (2008). "Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species." RNA 14(1);158-69. PMID: 18025252
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