|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Polynucleotide-Reactions → RNA-Reactions → tRNA-Reactions|
EC Number: 22.214.171.124
In Pathway: tRNA methylation (yeast)
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: tRNASer (uridine44-2′-O)-methyltransferase
Enzyme Commission Synonyms: TRM44
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -24.902222 [Latendresse13]
Enzyme Commission Summary:
The 2'-O-methylation of uridine44 contributes to stability of tRNASer(CGA).
Kotelawala08: Kotelawala L, Grayhack EJ, Phizicky EM (2008). "Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species." RNA 14(1);158-69. PMID: 18025252
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