MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Macromolecule Reactions Polynucleotide-Reactions RNA-Reactions tRNA-Reactions

EC Number:

Enzymes and Genes:

Saccharomyces cerevisiae : tRNASer (uridine44-2′-O)-methyltransferase Inferred from experiment : TRM44

In Pathway: tRNA methylation (yeast)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: tRNASer (uridine44-2′-O)-methyltransferase

Enzyme Commission Synonyms: TRM44

Standard Gibbs Free Energy (ΔrG in kcal/mol): -24.902222 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The 2'-O-methylation of uridine44 contributes to stability of tRNASer(CGA).

Citations: [Kotelawala08]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Created 28-Apr-2011 by Kothari A , SRI International


Kotelawala08: Kotelawala L, Grayhack EJ, Phizicky EM (2008). "Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species." RNA 14(1);158-69. PMID: 18025252

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Jul 27, 2015, BIOCYC13A.