MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Corynebacterium glutamicum ATCC 13032 : Zn2+-dependent alcohol dehydrogenase Inferred from experiment : adhA

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: alcohol dehydrogenase

Enzyme Commission Synonyms: aldehyde reductase, ADH, alcohol dehydrogenase (NAD), aliphatic alcohol dehydrogenase, ethanol dehydrogenase, NAD-dependent alcohol dehydrogenase, NAD-specific aromatic alcohol dehydrogenase, NADH-alcohol dehydrogenase, NADH-aldehyde dehydrogenase, primary alcohol dehydrogenase, yeast alcohol dehydrogenase

Taxonomic Range: Fungi , Archaea , Viridiplantae , Metazoa , Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): 21.624023 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A zinc protein. Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

Citations: [Jornvall77a, THEORELL58]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reactions of [a primary alcohol + NAD+ ↔ an aldehyde + NADH + H+] (
i1: 1-hexanol + NAD+ ← hexanal + NADH + H+ (1.1.1.-)

i2: 1-octanol + NAD+ = octanal + NADH + H+ (

i3: butanal + NADH + H+ → n-butanol + NAD+ (1.1.1.-)

i4: ethanol + NAD+ ↔ acetaldehyde + NADH + H+ (

i5: phytol + NAD+ → phytenal + NADH + H+ (

i6: n-propanol + NAD+ ↔ propanal + NADH + H+ (

Unification Links: Rhea:10743

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Created 15-Jun-2011 by Caspi R , SRI International


Jornvall77a: Jornvall H (1977). "Differences between alcohol dehydrogenases. Structural properties and evolutionary aspects." Eur J Biochem 72(3);443-52. PMID: 320001

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

THEORELL58: THEORELL H (1958). "Kinetics and equilibria in the liver alcohol dehydrogenase system." Adv Enzymol Relat Subj Biochem 20;31-49. PMID: 13605979

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Wed Jul 29, 2015, biocyc14.