Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.1.1.314

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Composite Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.314

Enzymes and Genes:
sesquiterpene dehydrogenase ( Cichorium intybus )
germacrene A alcohol dehydrogenase/hydroxylase Inferred from experiment : GAO1 ( Barnadesia spinosa )
germacrene A alcohol dehydrogenase/hydroxylase Inferred from experiment : GAO1 ( Cichorium intybus )
germacrene A alcohol dehydrogenase/hydroxylase Inferred from experiment : GAO1 ( Lactuca sativa )
germacrene A oxidase : GAO ( Tanacetum parthenium )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: germacrene A alcohol dehydrogenase

Sub-reactions:
germacra-1(10),4,11(13)-trien-12-ol + NADP+ → germacra-1(10),4,11(13)-trien-12-al + NADPH + H+ ,
germacra-1(10),4,11(13)-trien-12-al + NADP+ + H2O → germacra-1(10),4,11(13)-trien-12-oate + NADPH + 2 H+

Standard Gibbs Free Energy (ΔrG in kcal/mol): -14.610046 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This is an overall reaction that includes the two reactions listed above.

In Lactuca sativa EC 1.1.1.314 is a mutifunctional enzyme that also catalyzes EC 1.14.13.123, germacrene A hydroxylase [Nguyen10a].

Citations: [deKraker01]

Gene-Reaction Schematic: ?

Unification Links: Rhea:30670

Relationship Links: BRENDA:EC:1.1.1.314 , ENZYME:EC:1.1.1.314 , IUBMB-ExplorEnz:EC:1.1.1.314

Credits:
Created 15-Jun-2011 by Caspi R , SRI International


References

deKraker01: de Kraker JW, Franssen MC, Dalm MC, de Groot A, Bouwmeester HJ (2001). "Biosynthesis of germacrene A carboxylic acid in chicory roots. Demonstration of a cytochrome P450 (+)-germacrene a hydroxylase and NADP+-dependent sesquiterpenoid dehydrogenase(s) involved in sesquiterpene lactone biosynthesis." Plant Physiol 125(4);1930-40. PMID: 11299372

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nguyen10a: Nguyen DT, Gopfert JC, Ikezawa N, Macnevin G, Kathiresan M, Conrad J, Spring O, Ro DK (2010). "Biochemical conservation and evolution of germacrene A oxidase in asteraceae." J Biol Chem 285(22);16588-98. PMID: 20351109


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, biocyc13.