|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 184.108.40.206
Enzymes and Genes:
|Mycobacterium tuberculosis:||3-oxocholest-4-en-26-oate--CoA ligase: fadD19|
|Rhodococcus rhodochrous:||3-oxocholest-4-en-26-oate–CoA ligase: fadD19|
|Saccharomyces cerevisiae:||medium-chain acyl-CoA synthetase: FAA2|
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 3-oxocholest-4-en-26-oate—CoA ligase
Enzyme Commission Synonyms: fadD19 (gene name)
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -12.71167 [Latendresse13]
Enzyme Commission Summary:
The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyses a step in the degradation of cholesterol. It is responsible for the activation of the C8 side chain. 3β-hydroxycholest-5-en-26-oate can also be used as substrate.
Wilbrink11: Wilbrink MH, Petrusma M, Dijkhuizen L, van der Geize R (2011). "FadD19 of Rhodococcus rhodochrous DSM43269, a steroid-coenzyme A ligase essential for degradation of C-24 branched sterol side chains." Appl Environ Microbiol 77(13);4455-64. PMID: 21602385
©2015 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493