Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
twitter

MetaCyc Reaction: 6.2.1.42

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 6.2.1.42

Enzymes and Genes:

Mycobacterium tuberculosis: 3-oxocholest-4-en-26-oate--CoA ligaseInferred from experiment: fadD19
Rhodococcus rhodochrous: 3-oxocholest-4-en-26-oate–CoA ligaseInferred from experiment: fadD19
Saccharomyces cerevisiae: medium-chain acyl-CoA synthetase: FAA2

In Pathway: cholesterol degradation to androstenedione II (cholesterol dehydrogenase), cholesterol degradation to androstenedione I (cholesterol oxidase)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 3-oxocholest-4-en-26-oate—CoA ligase

Enzyme Commission Synonyms: fadD19 (gene name)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -12.71167Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyses a step in the degradation of cholesterol. It is responsible for the activation of the C8 side chain. 3β-hydroxycholest-5-en-26-oate can also be used as substrate.

Citations: [Casabon14, Wilbrink11 ]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:6.2.1.42, ENZYME:EC:6.2.1.42, IUBMB-ExplorEnz:EC:6.2.1.42

Credits:
Created 04-Oct-2011 by Caspi R, SRI International


References

Casabon14: Casabon I, Swain K, Crowe AM, Eltis LD, Mohn WW (2014). "Actinobacterial acyl coenzyme a synthetases involved in steroid side-chain catabolism." J Bacteriol 196(3);579-87. PMID: 24244004

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Wilbrink11: Wilbrink MH, Petrusma M, Dijkhuizen L, van der Geize R (2011). "FadD19 of Rhodococcus rhodochrous DSM43269, a steroid-coenzyme A ligase essential for degradation of C-24 branched sterol side chains." Appl Environ Microbiol 77(13);4455-64. PMID: 21602385


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Feb 10, 2016, biocyc11.