Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.1.1.14

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.1.1.14

In Pathway: seleno-amino acid biosynthesis

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 5-methyltetrahydropteroyltriglutamate—homocysteine S-methyltransferase

Enzyme Commission Synonyms: tetrahydropteroyltriglutamate methyltransferase, homocysteine methylase, methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase, methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase, cobalamin-independent methionine synthase, methionine synthase (cobalamin-independent), MetE

Standard Gibbs Free Energy (ΔrG in kcal/mol): -15.920031 Inferred by computational analysis [Latendresse13]

Summary:
The enzyme from Escherichia coli acts only on 5-methyl-tetrahydropteroylpolyglutamate (CH3-H4PteGlun) molecules which contain 2 or more glutamate residues [Zhou99a].

Enzyme Commission Summary:
The enzyme from Escherichia coli acts only on 5-methyl-tetrahydropteroylpolyglutamate (CH3-H4PteGlun) molecules which contain 2 or more glutamate residues [Zhou99a].

Citations: [Zhou00a, Gonzalez96, Eichel95, Whitfield70, Guest64]

Relationship Links: BRENDA:EC:2.1.1.14 , ENZYME:EC:2.1.1.14 , IUBMB-ExplorEnz:EC:2.1.1.14

Credits:
Created 07-Oct-2011 by Dreher KA , PMN


References

Eichel95: Eichel J, Gonzalez JC, Hotze M, Matthews RG, Schroder J (1995). "Vitamin-B12-independent methionine synthase from a higher plant (Catharanthus roseus). Molecular characterization, regulation, heterologous expression, and enzyme properties." Eur J Biochem 230(3);1053-8. PMID: 7601135

Gonzalez96: Gonzalez JC, Peariso K, Penner-Hahn JE, Matthews RG (1996). "Cobalamin-independent methionine synthase from Escherichia coli: a zinc metalloenzyme." Biochemistry 35(38);12228-34. PMID: 8823155

Guest64: Guest JR, Friedman S, Foster MA, Tejerina G, Woods DD (1964). "Transfer of the methyl group from N5-methyltetrahydrofolates to homocysteine in Escherichia coli." Biochem J 92(3);497-504. PMID: 5319972

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Whitfield70: Whitfield CD, Steers EJ, Weisbach H (1970). "Purification and properties of 5-methyltetrahydropteroyltriglutamate-homocysteine transmethylase." J Biol Chem 1970;245(2);390-401. PMID: 4904482

Zhou00a: Zhou ZS, Smith AE, Matthews RG (2000). "L-Selenohomocysteine: one-step synthesis from L-selenomethionine and kinetic analysis as substrate for methionine synthases." Bioorg Med Chem Lett 10(21);2471-5. PMID: 11078203

Zhou99a: Zhou ZS, Peariso K, Penner-Hahn JE, Matthews RG (1999). "Identification of the zinc ligands in cobalamin-independent methionine synthase (MetE) from Escherichia coli." Biochemistry 1999;38(48);15915-26. PMID: 10625458


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC13B.