MetaCyc Reaction: 1.14.13.-

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 1.14.13.-

Sub-reaction of: linalool + 2 NADH + 2 H+ + 2 oxygen → (6E)-8-oxolinalool + 2 NAD+ + 3 H2O

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1.14.13 -- With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Standard Gibbs Free Energy (ΔrG in kcal/mol): -102.42581Inferred by computational analysis [Latendresse13]

A heme-thiolate protein (P-450). The secondary electron donor is a specific [2Fe-2S] ferredoxin from the same bacterial strain.

Citations: [Bhattacharyya84, Ullah90, Ropp93]

Unification Links: Rhea:32639

Created 23-Jan-2012 by Caspi R, SRI International


Bhattacharyya84: Bhattacharyya, P.K., Samanta, T.B., Ullah, A.H.J., Gunsalus, I.C. (1984). "Chemical probes into the active centre of a heme thiolate monoxygenase." Proc. Indian Acad. Sci., Chem. Sci. 93: 1289-1304.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Ropp93: Ropp JD, Gunsalus IC, Sligar SG (1993). "Cloning and expression of a member of a new cytochrome P-450 family: cytochrome P-450lin (CYP111) from Pseudomonas incognita." J Bacteriol 175(18);6028-37. PMID: 8376348

Ullah90: Ullah AJ, Murray RI, Bhattacharyya PK, Wagner GC, Gunsalus IC (1990). "Protein components of a cytochrome P-450 linalool 8-methyl hydroxylase." J Biol Chem 265(3);1345-51. PMID: 2295633

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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