MetaCyc Reaction: 1.14.13.-

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.14.13.-

Sub-reaction of: linalool + 2 NADH + 2 H+ + 2 oxygen → (6E)-8-oxolinalool + 2 NAD+ + 3 H2O

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1.14.13 -- With NADH or NADPH as one donor, and incorporation of one atom of oxygen

Standard Gibbs Free Energy (ΔrG in kcal/mol): -102.42581 Inferred by computational analysis [Latendresse13]

A heme-thiolate protein (P-450). The secondary electron donor is a specific [2Fe-2S] ferredoxin from the same bacterial strain.

Citations: [Bhattacharyya84, Ullah90, Ropp93]

Unification Links: Rhea:32639

Created 23-Jan-2012 by Caspi R , SRI International


Bhattacharyya84: Bhattacharyya, P.K., Samanta, T.B., Ullah, A.H.J., Gunsalus, I.C. (1984). "Chemical probes into the active centre of a heme thiolate monoxygenase." Proc. Indian Acad. Sci., Chem. Sci. 93: 1289-1304.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Ropp93: Ropp JD, Gunsalus IC, Sligar SG (1993). "Cloning and expression of a member of a new cytochrome P-450 family: cytochrome P-450lin (CYP111) from Pseudomonas incognita." J Bacteriol 175(18);6028-37. PMID: 8376348

Ullah90: Ullah AJ, Murray RI, Bhattacharyya PK, Wagner GC, Gunsalus IC (1990). "Protein components of a cytochrome P-450 linalool 8-methyl hydroxylase." J Biol Chem 265(3);1345-51. PMID: 2295633

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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