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MetaCyc Reaction: 2.3.1.198

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 2.3.1.198

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Instance reactions:
22-hydroxy-docosanoyl-CoA + sn-glycerol 3-phosphate = 2-ω-hydroxy-C22:0-LPA + coenzyme A (2.3.1.198)

22-carboxy-docosanoyl-CoA + sn-glycerol 3-phosphate = 2-C22:0-DCA-LPA + coenzyme A (2.3.1.198)

hexadecanedioyl-CoA + sn-glycerol 3-phosphate = sn-2-C16:0-DCA-LPA + coenzyme A (2.3.1.198)

docosanoyl-CoA + sn-glycerol 3-phosphate = 2-docosanoyl-glycerol 3-phosphate + coenzyme A (2.3.1.198)

Enzyme Commission Primary Name: glycerol-3-phosphate 2-O-acyltransferase

Enzyme Commission Synonyms: sn-2-glycerol-3-phosphate O-acyltransferase, glycerol-3-phosphate O-acyltransferase (ambiguous)

Taxonomic Range: Viridiplantae

Standard Gibbs Free Energy (ΔrG in kcal/mol): 253.16797Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A membrane- associated enzyme required for suberin or cutin synthesis in plants. Active with a wide range of acyl-CoA substrates (C16:0-C24:0). The enzyme from some sources has much higher activity with ω-oxidized acyl-CoAs. Some enzymes are bifunctional and have an additional phosphatase activity producing sn-2-monoacylglycerols. Can also catalyse the reaction of EC 2.3.1.15, glycerol-3-phosphate 1-O-acyltransferase, but less well.

Citations: [Yang10]

Unification Links: Rhea:33562

Relationship Links: BRENDA:EC:2.3.1.198, ENZYME:EC:2.3.1.198, IUBMB-ExplorEnz:EC:2.3.1.198

Credits:
Created 23-Feb-2012 by Caspi R, SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Yang10: Yang W, Pollard M, Li-Beisson Y, Beisson F, Feig M, Ohlrogge J (2010). "A distinct type of glycerol-3-phosphate acyltransferase with sn-2 preference and phosphatase activity producing 2-monoacylglycerol." Proc Natl Acad Sci U S A 107(26);12040-5. PMID: 20551224


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sun Feb 14, 2016, biocyc14.