Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.3.1.198

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.198

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Instance reactions:
hexadecanedioyl-CoA + sn-glycerol 3-phosphate = sn-2-C16:0-DCA-LPA + coenzyme A (2.3.1.198)

C22:0-DCA-CoA + sn-glycerol 3-phosphate = 2-C22:0-DCA-LPA + coenzyme A (2.3.1.198)

ω-hydroxy-C22:0-CoA + sn-glycerol 3-phosphate = 2-ω-hydroxy-C22:0-LPA + coenzyme A (2.3.1.198)

docosanoyl-CoA + sn-glycerol 3-phosphate = 2-docosanoyl-glycerol 3-phosphate + coenzyme A (2.3.1.198)

Enzyme Commission Primary Name: glycerol-3-phosphate 2-O-acyltransferase

Enzyme Commission Synonyms: sn-2-glycerol-3-phosphate O-acyltransferase, glycerol-3-phosphate O-acyltransferase (ambiguous)

Standard Gibbs Free Energy (ΔrG in kcal/mol): 253.16797 Inferred by computational analysis [Latendresse, 2013]

Enzyme Commission Summary:
A membrane- associated enzyme required for suberin or cutin synthesis in plants. Active with a wide range of acyl-CoA substrates (C16:0-C24:0). The enzyme from some sources has much higher activity with ω-oxidized acyl-CoAs. Some enzymes are bifunctional and have an additional phosphatase activity producing sn-2-monoacylglycerols. Can also catalyse the reaction of EC 2.3.1.15, glycerol-3-phosphate 1-O-acyltransferase, but less well.

Citations: [Yang10]

Unification Links: Rhea:33562

Relationship Links: BRENDA:EC:2.3.1.198 , ENZYME:EC:2.3.1.198 , IUBMB-ExplorEnz:EC:2.3.1.198

Credits:
Created 23-Feb-2012 by Caspi R , SRI International


References

Latendresse, 2013: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Yang10: Yang W, Pollard M, Li-Beisson Y, Beisson F, Feig M, Ohlrogge J (2010). "A distinct type of glycerol-3-phosphate acyltransferase with sn-2 preference and phosphatase activity producing 2-monoacylglycerol." Proc Natl Acad Sci U S A 107(26);12040-5. PMID: 20551224


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, biocyc13.