|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
22-hydroxy-docosanoyl-CoA + sn-glycerol 3-phosphate = 2-ω-hydroxy-C22:0-LPA + coenzyme A (184.108.40.206)
22-carboxy-docosanoyl-CoA + sn-glycerol 3-phosphate = 2-C22:0-DCA-LPA + coenzyme A (220.127.116.11)
hexadecanedioyl-CoA + sn-glycerol 3-phosphate = sn-2-C16:0-DCA-LPA + coenzyme A (18.104.22.168)
docosanoyl-CoA + sn-glycerol 3-phosphate = 2-docosanoyl-glycerol 3-phosphate + coenzyme A (22.214.171.124)
Enzyme Commission Primary Name: glycerol-3-phosphate 2-O-acyltransferase
Enzyme Commission Synonyms: sn-2-glycerol-3-phosphate O-acyltransferase, glycerol-3-phosphate O-acyltransferase (ambiguous)
Taxonomic Range: Viridiplantae
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 253.16797 [Latendresse13]
Enzyme Commission Summary:
A membrane- associated enzyme required for suberin or cutin synthesis in plants. Active with a wide range of acyl-CoA substrates (C16:0-C24:0). The enzyme from some sources has much higher activity with ω-oxidized acyl-CoAs. Some enzymes are bifunctional and have an additional phosphatase activity producing sn-2-monoacylglycerols. Can also catalyse the reaction of EC 126.96.36.199, glycerol-3-phosphate 1-O-acyltransferase, but less well.
Unification Links: Rhea:33562
Yang10: Yang W, Pollard M, Li-Beisson Y, Beisson F, Feig M, Ohlrogge J (2010). "A distinct type of glycerol-3-phosphate acyltransferase with sn-2 preference and phosphatase activity producing 2-monoacylglycerol." Proc Natl Acad Sci U S A 107(26);12040-5. PMID: 20551224
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