MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Instance reactions:
docosanoyl-CoA + sn-glycerol 3-phosphate = 2-docosanoyl-glycerol 3-phosphate + coenzyme A (

ω-hydroxy-C22:0-CoA + sn-glycerol 3-phosphate = 2-ω-hydroxy-C22:0-LPA + coenzyme A (

C22:0-DCA-CoA + sn-glycerol 3-phosphate = 2-C22:0-DCA-LPA + coenzyme A (

hexadecanedioyl-CoA + sn-glycerol 3-phosphate = sn-2-C16:0-DCA-LPA + coenzyme A (

Enzyme Commission Primary Name: glycerol-3-phosphate 2-O-acyltransferase

Enzyme Commission Synonyms: sn-2-glycerol-3-phosphate O-acyltransferase, glycerol-3-phosphate O-acyltransferase (ambiguous)

Taxonomic Range: Viridiplantae

Standard Gibbs Free Energy (ΔrG in kcal/mol): 253.16797 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A membrane- associated enzyme required for suberin or cutin synthesis in plants. Active with a wide range of acyl-CoA substrates (C16:0-C24:0). The enzyme from some sources has much higher activity with ω-oxidized acyl-CoAs. Some enzymes are bifunctional and have an additional phosphatase activity producing sn-2-monoacylglycerols. Can also catalyse the reaction of EC, glycerol-3-phosphate 1-O-acyltransferase, but less well.

Citations: [Yang10b]

Unification Links: Rhea:33562

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Created 23-Feb-2012 by Caspi R , SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Yang10b: Yang W, Pollard M, Li-Beisson Y, Beisson F, Feig M, Ohlrogge J (2010). "A distinct type of glycerol-3-phosphate acyltransferase with sn-2 preference and phosphatase activity producing 2-monoacylglycerol." Proc Natl Acad Sci U S A 107(26);12040-5. PMID: 20551224

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Mar 29, 2015, biocyc13.