Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.5.5.8

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.5.5.8

Enzymes and Genes:
thiocyanate hydrolase Inferred from experiment : scnA , scnB , scnC ( Thiobacillus thioparus THI 115 )

In Pathway: thiocyanate degradation II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: thiocyanate hydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 37.684002 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This reaction is different from the one described by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB). The reaction is different in that the official EC reaction represents the ionic form of thiocyanate (NCS -), and thus requires an hydroxy group on the products side in order to balance it.

Citations: [Katayama92, Katayama98]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R05780 , Rhea:21465

Relationship Links: BRENDA:EC:3.5.5.8 , ENZYME:EC:3.5.5.8 , IUBMB-ExplorEnz:EC:3.5.5.8


References

Katayama92: Katayama Y, Narahara Y, Inoue Y, Amano F, Kanagawa T, Kuraishi H (1992). "A thiocyanate hydrolase of Thiobacillus thioparus. A novel enzyme catalyzing the formation of carbonyl sulfide from thiocyanate." J Biol Chem 1992;267(13);9170-5. PMID: 1577754

Katayama98: Katayama Y, Matsushita Y, Kaneko M, Kondo M, Mizuno T, Nyunoya H (1998). "Cloning of genes coding for the three subunits of thiocyanate hydrolase of Thiobacillus thioparus THI 115 and their evolutionary relationships to nitrile hydratase." J Bacteriol 1998;180(10);2583-9. PMID: 9573140

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC13A.