MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Thiobacillus thioparus THI 115: thiocyanate hydrolaseInferred from experiment: scnA, scnB, scnC

In Pathway: thiocyanate degradation II

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: thiocyanate hydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 37.684002Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This reaction is different from the one described by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB). The reaction is different in that the official EC reaction represents the ionic form of thiocyanate (NCS -), and thus requires an hydroxy group on the products side in order to balance it.

Citations: [Katayama92 , Katayama98]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R05780, Rhea:21465

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Katayama92: Katayama Y, Narahara Y, Inoue Y, Amano F, Kanagawa T, Kuraishi H (1992). "A thiocyanate hydrolase of Thiobacillus thioparus. A novel enzyme catalyzing the formation of carbonyl sulfide from thiocyanate." J Biol Chem 1992;267(13);9170-5. PMID: 1577754

Katayama98: Katayama Y, Matsushita Y, Kaneko M, Kondo M, Mizuno T, Nyunoya H (1998). "Cloning of genes coding for the three subunits of thiocyanate hydrolase of Thiobacillus thioparus THI 115 and their evolutionary relationships to nitrile hydratase." J Bacteriol 1998;180(10);2583-9. PMID: 9573140

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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