|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
Enzymes and Genes:
|Thiobacillus thioparus THI 115 :||thiocyanate hydrolase
In Pathway: thiocyanate degradation II
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: thiocyanate hydrolase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 37.684002 [Latendresse13]
Enzyme Commission Summary:
This reaction is different from the one described by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB). The reaction is different in that the official EC reaction represents the ionic form of thiocyanate (NCS -), and thus requires an hydroxy group on the products side in order to balance it.
Katayama92: Katayama Y, Narahara Y, Inoue Y, Amano F, Kanagawa T, Kuraishi H (1992). "A thiocyanate hydrolase of Thiobacillus thioparus. A novel enzyme catalyzing the formation of carbonyl sulfide from thiocyanate." J Biol Chem 1992;267(13);9170-5. PMID: 1577754
Katayama98: Katayama Y, Matsushita Y, Kaneko M, Kondo M, Mizuno T, Nyunoya H (1998). "Cloning of genes coding for the three subunits of thiocyanate hydrolase of Thiobacillus thioparus THI 115 and their evolutionary relationships to nitrile hydratase." J Bacteriol 1998;180(10);2583-9. PMID: 9573140
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