|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
Enzymes and Genes:
|Comamonas testosteroni:||4-carboxy-2-hydroxymuconate hydratase: pmdE|
|Pseudomonas putida KT2440:||4-oxalmesaconate hydratase: galB|
|Pseudomonas straminea:||4-oxalomesaconate hydratase: proH|
|Sphingomonas sp. SYK6:||4-oxalomesaconate hydratase: ligJ|
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 4-oxalomesaconate hydratase
Enzyme Commission Synonyms: 4-oxalmesaconate hydratase, 4-carboxy-2-oxohexenedioate hydratase, 4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase, oxalmesaconate hydratase, γ-oxalmesaconate hydratase, 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase, LigJ, GalB
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 6.423004 [Latendresse13]
Enzyme Commission Summary:
This enzyme participates in the degradation of protocatechuate (via the meta-cleavage pathway), syringate and gallate [Maruyama83, Maruyama85, Hara00]. It accepts the enol-form of 4-oxalomesaconate, 2-hydroxy-4-carboxy-hexa-2,4-dienedioate [Nogales11].
Hara00: Hara H, Masai E, Katayama Y, Fukuda M (2000). "The 4-oxalomesaconate hydratase gene, involved in the protocatechuate 4,5-cleavage pathway, is essential to vanillate and syringate degradation in Sphingomonas paucimobilis SYK-6." J Bacteriol 182(24);6950-7. PMID: 11092855
Nogales11: Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E (2011). "Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida." Mol Microbiol 79(2);359-74. PMID: 21219457
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