Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.1.1.46

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.1.1.46

Enzymes and Genes:
isoflavone-4'-O-methyltransferase Inferred from experiment ( Cicer arietinum )

In Pathway: formononetin biosynthesis

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
a 4'-hydroxyisoflavone + S-adenosyl-L-methionine → a 4'-methoxyisoflavone + S-adenosyl-L-homocysteine + H+ (2.1.1.46)

Enzyme Commission Primary Name: isoflavone 4′-O-methyltransferase

Enzyme Commission Synonyms: 4'-hydroxyisoflavone methyltransferase, isoflavone methyltransferase, isoflavone O-methyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 7.7590027 Inferred by computational analysis [Latendresse13]

Summary:
Requires Mg2+ for activity. The enzyme catalyses the methylation of daidzein and genistein. It does not methylate naringenin, apigenin, luteolin or kaempferol.

Enzyme Commission Summary:
Requires Mg2+ for activity. The enzyme catalyses the methylation of daidzein and genistein. It does not methylate naringenin, apigenin, luteolin or kaempferol.

Citations: [Wengenmayer74]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R06564

Relationship Links: BRENDA:EC:2.1.1.46 , ENZYME:EC:2.1.1.46 , IUBMB-ExplorEnz:EC:2.1.1.46

Credits:
Revised 07-Oct-2011 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Wengenmayer74: Wengenmayer H, Ebel J, Grisebach H (1974). "Purification and properties of a S-adenosylmethionine: isoflavone 4'-O-methyltransferase from cell suspension cultures of Cicer arietinum L." Eur J Biochem 50(1);135-43. PMID: 4452353


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc13.