Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
twitter

MetaCyc Reaction: 2.1.1.46

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 2.1.1.46

Enzymes and Genes:

Cicer arietinum: isoflavone-4'-O-methyltransferaseInferred from experiment

In Pathway: formononetin biosynthesis

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
a 4'-hydroxyisoflavone + S-adenosyl-L-methionine → a 4'-methoxyisoflavone + S-adenosyl-L-homocysteine + H+ (2.1.1.46)

Enzyme Commission Primary Name: isoflavone 4′-O-methyltransferase

Enzyme Commission Synonyms: 4'-hydroxyisoflavone methyltransferase, isoflavone methyltransferase, isoflavone O-methyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 7.7590027Inferred by computational analysis [Latendresse13]

Summary:
Requires Mg2+ for activity. The enzyme catalyses the methylation of daidzein and genistein. It does not methylate naringenin, apigenin, luteolin or kaempferol.

Enzyme Commission Summary:
Requires Mg2+ for activity. The enzyme catalyses the methylation of daidzein and genistein. It does not methylate naringenin, apigenin, luteolin or kaempferol.

Citations: [Wengenmayer74]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R06564

Relationship Links: BRENDA:EC:2.1.1.46, ENZYME:EC:2.1.1.46, IUBMB-ExplorEnz:EC:2.1.1.46

Credits:
Revised 07-Oct-2011 by Caspi R, SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Wengenmayer74: Wengenmayer H, Ebel J, Grisebach H (1974). "Purification and properties of a S-adenosylmethionine: isoflavone 4'-O-methyltransferase from cell suspension cultures of Cicer arietinum L." Eur J Biochem 50(1);135-43. PMID: 4452353


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Thu Feb 11, 2016, biocyc14.