|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 2-haloacid dehalogenase (configuration-retaining)
Enzyme Commission Synonyms: 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, DL-2-haloacid dehalogenase, DL-DEXr
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -5.2382355 [Latendresse13]
Enzyme Commission Summary:
Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids, respectively, with retention of configuration at C-2. [See also EC 22.214.171.124 (S)-2-haloacid dehalogenase, EC 126.96.36.199 (R)-2-haloacid dehalogenase and EC 188.8.131.52 2-haloacid dehalogenase (configuration-inverting)] [Weightman82].
Unification Links: KEGG:R07310
Weightman82: Weightman AJ, Weightman AL, Slater JH (1982). "Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas putida PP3: evidence for two different dehalogenation mechanisms." J Gen Microbiol 128(8);1755-62. PMID: 7142958
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