Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.1.3.25

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.3.25

Enzymes and Genes:
phytase / 4-phytase Inferred from experiment ( Triticum aestivum )
inositol monophosphatase 3 : IMPAD1 ( Homo sapiens )
myo-inositol monophosphatase 2 : IMPA2 ( Homo sapiens )
inositol monophosphatase 1 : IMPA1 ( Homo sapiens )

In Pathway: phytate degradation I

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Direct generic reaction:
a myo-inositol monophosphate + H2O → myo-inositol + phosphate (3.1.3.25)

Enzyme Commission Primary Name: inositol-phosphate phosphatase

Enzyme Commission Synonyms: myo-inositol-1(or 4)-monophosphatase, inositol 1-phosphatase, L-myo-inositol-1-phosphate phosphatase, myo-inositol 1-phosphatase, inositol phosphatase, inositol monophosphate phosphatase, inositol-1(or 4)-monophosphatase, myo-inositol-1(or 4)-phosphate phosphohydrolase, myo-inositol monophosphatase, myo-inositol-1-phosphatase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 7.2170105 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group. It also acts on adenosine 2'-phosphate (but not the 3'- or 5'- phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate. Two isoforms are known [Yoshikawa97].

Citations: [Eisenberg67, Gee88, Hallcher80, Woscholski00, Ackermann87]

Gene-Reaction Schematic: ?

Instance reaction of [1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + H2O → a D myo-inositol penta kis phosphate + phosphate] (3.1.3.62):
i7: 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + H2O → D-myo-inositol (1,2,3,5,6) pentakisphosphate + phosphate (3.1.3.26)

Instance reactions of [a myo-inositol monophosphate + H2O → myo-inositol + phosphate] (3.1.3.25):
i14: 1D-myo-inositol 3-monophosphate + H2O → myo-inositol + phosphate (3.1.3.25)

i15: 1D-myo-inositol 5-monophosphate + H2O → myo-inositol + phosphate (3.1.3.25)

i16: 1D-myo-inositol 6-monophosphate + H2O → myo-inositol + phosphate (3.1.3.25)

i17: 1D-myo-inositol 2-monophosphate + H2O → myo-inositol + phosphate (3.1.3.25)
i18: 1D-myo-inositol 1-monophosphate + H2O → myo-inositol + phosphate (3.1.3.25)

i19: 1D-myo-inositol 4-monophosphate + H2O → myo-inositol + phosphate (3.1.3.25)

Relationship Links: BRENDA:EC:3.1.3.25 , ENZYME:EC:3.1.3.25 , IUBMB-ExplorEnz:EC:3.1.3.25


References

Ackermann87: Ackermann KE, Gish BG, Honchar MP, Sherman WR (1987). "Evidence that inositol 1-phosphate in brain of lithium-treated rats results mainly from phosphatidylinositol metabolism." Biochem J 242(2);517-24. PMID: 3036092

Eisenberg67: Eisenberg F (1967). "D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis." J Biol Chem 242(7);1375-82. PMID: 4290245

Gee88: Gee NS, Ragan CI, Watling KJ, Aspley S, Jackson RG, Reid GG, Gani D, Shute JK (1988). "The purification and properties of myo-inositol monophosphatase from bovine brain." Biochem J 249(3);883-9. PMID: 2833231

Hallcher80: Hallcher LM, Sherman WR (1980). "The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain." J Biol Chem 255(22);10896-901. PMID: 6253491

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Woscholski00: Woscholski, R., Parker, P.J (2000). "Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates. In: Cockcroft, S. (Ed.),." Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford,.

Yoshikawa97: Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder." Mol Psychiatry 2(5);393-7. PMID: 9322233


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC13A.