Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.5.1.53

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.5.1.53

Enzymes and Genes:
willardiine synthase Inferred from experiment ( Pisum sativum )

In Pathway: willardiine and isowillardiine biosynthesis

Supersedes EC number: 4.2.99.16

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: uracilylalanine synthase

Enzyme Commission Synonyms: O3-acetyl-L-serine acetate-lyase (adding uracil), isowillardiine synthase, willardiine synthase, 3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase, O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -3.5541077 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme produces the non-proteinogenic amino acid L-willardiine, which is naturally found in the plants Mariosousa willardiana, Mimosa pigra, and Pisum sativum (pea). The enzyme from Pisum species also produces L-isowillardiine. Not identical with EC 2.5.1.47, cysteine synthase.

Citations: [Ahmmad84, Ikegami87, Murakoshi78]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R03131 , Rhea:11496

Relationship Links: BRENDA:EC:2.5.1.53 , ENZYME:EC:2.5.1.53 , IUBMB-ExplorEnz:EC:2.5.1.53


References

Ahmmad84: Ahmmad, Mohammad A.S., Maskall, C. Sidney, Brown, Eric G. (1984). "Partial purification and properties of willardiine and isowillardiine synthase activity from Pisum sativum." Phytochemistry, 1984, 23(2):265-270.

Ikegami87: Ikegami F, Kaneko M, Lambein F, Kuo Y-H, Murakoshi I (1987). "Difference between uracilylalanine synthases and cysteine synthases in Pisum sativum." Phytochemistry 26 2699-2704.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Murakoshi78: Murakoshi, Isamu, Ikegami, Fumio, Ookawa, Noriyuki, Ariki, Takuichi, Haginiwa, Joju, Kuo, Yu-Haey (1978). "Biosynthesis of the uracilylalanines willardiine and isowillardiine in higher plants." Phytochemistry, 1978, 17:1571-1576.


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC13B.