MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Pisum sativum: willardiine synthaseInferred from experiment

In Pathway: willardiine and isowillardiine biosynthesis

Supersedes EC number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: uracilylalanine synthase

Enzyme Commission Synonyms: O3-acetyl-L-serine acetate-lyase (adding uracil), isowillardiine synthase, willardiine synthase, 3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase, O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -3.5541077Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme produces the non-proteinogenic amino acid L-willardiine, which is naturally found in the plants Mariosousa willardiana, Mimosa pigra, and Pisum sativum (pea). The enzyme from Pisum species also produces L-isowillardiine. Not identical with EC, cysteine synthase.

Citations: [Ahmmad84, Ikegami87, Murakoshi78]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R03131, Rhea:11496

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Ahmmad84: Ahmmad, Mohammad A.S., Maskall, C. Sidney, Brown, Eric G. (1984). "Partial purification and properties of willardiine and isowillardiine synthase activity from Pisum sativum." Phytochemistry, 1984, 23(2):265-270.

Ikegami87: Ikegami F, Kaneko M, Lambein F, Kuo Y-H, Murakoshi I (1987). "Difference between uracilylalanine synthases and cysteine synthases in Pisum sativum." Phytochemistry 26 2699-2704.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Murakoshi78: Murakoshi, Isamu, Ikegami, Fumio, Ookawa, Noriyuki, Ariki, Takuichi, Haginiwa, Joju, Kuo, Yu-Haey (1978). "Biosynthesis of the uracilylalanines willardiine and isowillardiine in higher plants." Phytochemistry, 1978, 17:1571-1576.

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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