|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
Enzymes and Genes:
|Escherichia coli K-12 substr. MG1655:||alkaline phosphatase: phoA|
purine nucleotidase: yrfG
UMP phosphatase: umpH
acid phosphatase / phosphotransferase: aphA
|Homo sapiens:||cytosolic 5'-nucleotidase II: NT5C2|
|Saccharomyces cerevisiae:||IMP-specific 5'-nucleotidase: ISN1|
In Pathway: adenosine nucleotides degradation I
Reaction Locations: cytosol, periplasm (sensu Gram-negative Bacteria)
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
Enzyme Commission Primary Name for 184.108.40.206: 5′-nucleotidase
Enzyme Commission Synonyms for 220.127.116.11: uridine 5'-nucleotidase, 5'-adenylic phosphatase, adenosine 5'-phosphatase, AMP phosphatase, adenosine monophosphatase, 5'-mononucleotidase, AMPase, UMPase, snake venom 5'-nucleotidase, thimidine monophosphate nucleotidase, 5'-AMPase, 5'-AMP nucleotidase, AMP phosphohydrolase, IMP 5'-nucleotidase
Enzyme Commission Primary Name for 3.1.3.v: IMP-specific 5'-nucleotidase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 7.2170105 [Latendresse13]
Enzyme Commission Summary for 18.104.22.168:
Wide specificity for 5-nucleotides.
Enzyme Commission Summary for 3.1.3.v:
The enzyme, isolated from the yeast Saccharomyces cerevisiae, is highly specific for IMP, and has no detectable activity with other purine and pyrimidine nucleotides. Requires divalent metals, such as Mg2+, Co2+ or Mn2+.
Instance reaction of [a ribonucleoside 5'-monophosphate + H2O → a ribonucleoside + phosphate] (22.214.171.124):
i1: IMP + H2O → inosine + phosphate (126.96.36.199/3.1.3.v)
Itoh03: Itoh R, Saint-Marc C, Chaignepain S, Katahira R, Schmitter JM, Daignan-Fornier B (2003). "The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5'-nucleotidase." BMC Biochem 4;4. PMID: 12735798
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