Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.1.3.5

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.3.5

Enzymes and Genes:
purine nucleotidase Inferred from experiment : yrfG ( Escherichia coli K-12 substr. MG1655 )
cytosolic 5'-nucleotidase II Inferred from experiment : NT5C2 ( Homo sapiens )
5'-nucleotidase Inferred from experiment ( Solanum tuberosum )
5'-nucleotidase : NT5E ( Homo sapiens )
broad specificity 5'(3')-nucleotidase and polyphosphatase : umpG ( Escherichia coli K-12 substr. MG1655 )
UMP phosphatase : umpH ( Escherichia coli K-12 substr. MG1655 )
acid phosphatase / phosphotransferase : aphA ( Escherichia coli K-12 substr. MG1655 )

In Pathway: guanosine nucleotides degradation II , guanosine nucleotides degradation I , guanosine nucleotides degradation III

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 5′-nucleotidase

Enzyme Commission Synonyms: uridine 5'-nucleotidase, 5'-adenylic phosphatase, adenosine 5'-phosphatase, AMP phosphatase, adenosine monophosphatase, 5'-mononucleotidase, AMPase, UMPase, snake venom 5'-nucleotidase, thimidine monophosphate nucleotidase, 5'-AMPase, 5'-AMP nucleotidase, AMP phosphohydrolase, IMP 5'-nucleotidase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 7.2170105 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Wide specificity for 5-nucleotides.

Citations: [Gulland38, Heppel51, Segal60]

Gene-Reaction Schematic: ?

Instance reaction of [a ribonucleoside 5'-monophosphate + H2O → a ribonucleoside + phosphate] (3.1.3.5):
i1: GMP + H2O → guanosine + phosphate (3.1.3.5)

Unification Links: KEGG:R01227 , Rhea:27714

Relationship Links: BRENDA:EC:3.1.3.5 , ENZYME:EC:3.1.3.5 , IUBMB-ExplorEnz:EC:3.1.3.5


References

Gulland38: Gulland JM, Jackson EM (1938). "5-Nucleotidase." Biochem J 32(3);597-601. PMID: 16746659

Heppel51: Heppel LA, Hilmore RJ (1951). "Purification and properties of 5-nucleotidase." J Biol Chem 188(2);665-76. PMID: 14824154

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Segal60: Segal HL, Brenner BM (1960). "5'-Nucleotidase of rat liver microsomes." J Biol Chem 235;471-4. PMID: 14444527


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC13B.