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MetaCyc Reaction: 1.1.1.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.1

Enzymes and Genes:

Saccharomyces cerevisiae : alcohol dehydrogenase / S-hydroxymethyl-glutathione dehydrogenase Inferred from experiment : SFA1
alcohol dehydrogenase I Inferred from experiment : ADH1
alcohol dehydrogenase II Inferred from experiment : ADH2
alcohol dehydrogenase III Inferred from experiment : ADH3
alcohol dehydrogenase IV Inferred from experiment : ADH4
alcohol dehydrogenase V Inferred from experiment : ADH5

In Pathway: L-isoleucine degradation II

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number, which can be found here and here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: alcohol dehydrogenase

Enzyme Commission Synonyms: aldehyde reductase, ADH, alcohol dehydrogenase (NAD), aliphatic alcohol dehydrogenase, ethanol dehydrogenase, NAD-dependent alcohol dehydrogenase, NAD-specific aromatic alcohol dehydrogenase, NADH-alcohol dehydrogenase, NADH-aldehyde dehydrogenase, primary alcohol dehydrogenase, yeast alcohol dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 2.541809 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A zinc protein. Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

Citations: [Jornvall77a, THEORELL58]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [S-hydroxymethylglutathione + NAD(P)+S-formylglutathione + NAD(P)H + H+] (1.1.1.284):
i7: S-hydroxymethylglutathione + NAD+ = S-formylglutathione + NADH + H+ (1.-.-.-)

Instance reactions of [a primary alcohol + NAD+ ↔ an aldehyde + NADH + H+] (1.1.1.1):
i1: phytol + NAD+ → phytenal + NADH + H+ (1.1.1.1)

i2: 1-octanol + NAD+ = octanal + NADH + H+ (1.1.1.73)

i3: 1-hexanol + NAD+ ← hexanal + NADH + H+ (1.1.1.-)

i4: n-propanol + NAD+ ↔ propanal + NADH + H+ (1.1.1.1)

i5: ethanol + NAD+ ↔ acetaldehyde + NADH + H+ (1.1.1.1)

i6: butanal + NADH + H+ → n-butanol + NAD+ (1.1.1.-)

Relationship Links: BRENDA:EC:1.1.1.1 , ENZYME:EC:1.1.1.1 , IUBMB-ExplorEnz:EC:1.1.1.1


References

Jornvall77a: Jornvall H (1977). "Differences between alcohol dehydrogenases. Structural properties and evolutionary aspects." Eur J Biochem 72(3);443-52. PMID: 320001

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

THEORELL58: THEORELL H (1958). "Kinetics and equilibria in the liver alcohol dehydrogenase system." Adv Enzymol Relat Subj Biochem 20;31-49. PMID: 13605979


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun May 24, 2015, biocyc12.