|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 184.108.40.206
Enzymes and Genes:
|Saccharomyces cerevisiae:||alcohol dehydrogenase / S-hydroxymethyl-glutathione dehydrogenase: SFA1|
alcohol dehydrogenase I: ADH1
alcohol dehydrogenase II: ADH2
alcohol dehydrogenase III: ADH3
alcohol dehydrogenase IV: ADH4
alcohol dehydrogenase V: ADH5
In Pathway: L-isoleucine degradation II
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: alcohol dehydrogenase
Enzyme Commission Synonyms: aldehyde reductase, ADH, alcohol dehydrogenase (NAD), aliphatic alcohol dehydrogenase, ethanol dehydrogenase, NAD-dependent alcohol dehydrogenase, NAD-specific aromatic alcohol dehydrogenase, NADH-alcohol dehydrogenase, NADH-aldehyde dehydrogenase, primary alcohol dehydrogenase, yeast alcohol dehydrogenase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 2.541809 [Latendresse13]
Enzyme Commission Summary:
A zinc protein. Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
Instance reaction of [S-hydroxymethylglutathione + NAD(P)+ ↔ S-formylglutathione + NAD(P)H + H+] (220.127.116.114):
i7: S-hydroxymethylglutathione + NAD+ = S-formylglutathione + NADH + H+ (1.-.-.-)
Instance reactions of [a primary alcohol + NAD+ ↔ an aldehyde + NADH + H+] (18.104.22.168):
i1: phytol + NAD+ → phytenal + NADH + H+ (22.214.171.124)
i2: 1-octanol + NAD+ = octanal + NADH + H+ (126.96.36.199)
i3: 1-hexanol + NAD+ ← hexanal + NADH + H+ (1.1.1.-)
i4: butanal + NADH + H+ → n-butanol + NAD+ (1.1.1.-)
i5: n-propanol + NAD+ ↔ propanal + NADH + H+ (188.8.131.52)
i6: ethanol + NAD+ ↔ acetaldehyde + NADH + H+ (184.108.40.206)
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