MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsProtein-Modification Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-ReactionsProtein-Modification Reactions

EC Number:

Enzymes and Genes:

Thunbergia alata: acyl-[acyl-carrier protein] 6-desaturaseInferred from experiment: pTAD4

In Pathway: sapienate biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: acyl-[acyl-carrier protein] 6-desaturase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -56.580048Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme, characterized from the plant Thunbergia alata (black-eyed Susan vine) endosperm, introduces a cis double bond at carbon 6 of several saturated acyl-[acp]s. It is most active with palmitoyl-[acp] (16:0), but can also act on myristoyl-[acp] (14:0) and stearoyl-[acp] (18:0). The position of the double bond is determined by its distance from the carboxyl end of the fatty acid.

Citations: [Cahoon94 , Cahoon97]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Cahoon94: Cahoon EB, Cranmer AM, Shanklin J, Ohlrogge JB (1994). "delta 6 Hexadecenoic acid is synthesized by the activity of a soluble delta 6 palmitoyl-acyl carrier protein desaturase in Thunbergia alata endosperm." J Biol Chem 269(44);27519-26. PMID: 7961667

Cahoon97: Cahoon EB, Lindqvist Y, Schneider G, Shanklin J (1997). "Redesign of soluble fatty acid desaturases from plants for altered substrate specificity and double bond position." Proc Natl Acad Sci U S A 94(10);4872-7. PMID: 9144157

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Thu Nov 26, 2015, BIOCYC13B.