MetaCyc Reaction: 1.14.19.n

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 1.14.19.n

Enzymes and Genes:

Thunbergia alata : acyl-[acyl-carrier protein] 6-desaturase Inferred from experiment : pTAD4

In Pathway: sapienate biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: acyl-[acyl-carrier protein] 6-desaturase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -56.580048 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme, characterized from the plant Thunbergia alata (black-eyed Susan vine) endosperm, introduces a cis double bond at carbon 6 of several saturated acyl-[acp]s. It is most active with palmitoyl-[acp] (16:0), but can also act on myristoyl-[acp] (14:0) and stearoyl-[acp] (18:0). It is a front-end desaturase, determining the position of the double bond by its distance from the carboxylic acid end of the fatty acid.

Citations: [Cahoon94, Cahoon97]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic


Cahoon94: Cahoon EB, Cranmer AM, Shanklin J, Ohlrogge JB (1994). "delta 6 Hexadecenoic acid is synthesized by the activity of a soluble delta 6 palmitoyl-acyl carrier protein desaturase in Thunbergia alata endosperm." J Biol Chem 269(44);27519-26. PMID: 7961667

Cahoon97: Cahoon EB, Lindqvist Y, Schneider G, Shanklin J (1997). "Redesign of soluble fatty acid desaturases from plants for altered substrate specificity and double bond position." Proc Natl Acad Sci U S A 94(10);4872-7. PMID: 9144157

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Oct 6, 2015, biocyc13.