|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Protein-Modification Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions → Protein-Modification Reactions|
EC Number: 126.96.36.199
Enzymes and Genes:
|Thunbergia alata:||acyl-[acyl-carrier protein] 6-desaturase: pTAD4|
In Pathway: sapienate biosynthesis
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: acyl-[acyl-carrier protein] 6-desaturase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -56.580048 [Latendresse13]
Enzyme Commission Summary:
The enzyme, characterized from the plant Thunbergia alata (black-eyed Susan vine) endosperm, introduces a cis double bond at carbon 6 of several saturated acyl-[acp]s. It is most active with palmitoyl-[acp] (16:0), but can also act on myristoyl-[acp] (14:0) and stearoyl-[acp] (18:0). The position of the double bond is determined by its distance from the carboxyl end of the fatty acid.
Cahoon94: Cahoon EB, Cranmer AM, Shanklin J, Ohlrogge JB (1994). "delta 6 Hexadecenoic acid is synthesized by the activity of a soluble delta 6 palmitoyl-acyl carrier protein desaturase in Thunbergia alata endosperm." J Biol Chem 269(44);27519-26. PMID: 7961667
Cahoon97: Cahoon EB, Lindqvist Y, Schneider G, Shanklin J (1997). "Redesign of soluble fatty acid desaturases from plants for altered substrate specificity and double bond position." Proc Natl Acad Sci U S A 94(10);4872-7. PMID: 9144157
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