|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Protein-Modification Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions → Protein-Modification Reactions|
EC Number: 1.14.19.n
In Pathway: sapienate biosynthesis
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: acyl-[acyl-carrier protein] 6-desaturase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -56.580048 [Latendresse13]
Enzyme Commission Summary:
The enzyme, characterized from the plant Thunbergia alata (black-eyed Susan vine) endosperm, introduces a cis double bond at carbon 6 of several saturated acyl-[acp]s. It is most active with palmitoyl-[acp] (16:0), but can also act on myristoyl-[acp] (14:0) and stearoyl-[acp] (18:0). It is a front-end desaturase, determining the position of the double bond by its distance from the carboxylic acid end of the fatty acid.
Cahoon94: Cahoon EB, Cranmer AM, Shanklin J, Ohlrogge JB (1994). "delta 6 Hexadecenoic acid is synthesized by the activity of a soluble delta 6 palmitoyl-acyl carrier protein desaturase in Thunbergia alata endosperm." J Biol Chem 269(44);27519-26. PMID: 7961667
Cahoon97: Cahoon EB, Lindqvist Y, Schneider G, Shanklin J (1997). "Redesign of soluble fatty acid desaturases from plants for altered substrate specificity and double bond position." Proc Natl Acad Sci U S A 94(10);4872-7. PMID: 9144157
©2014 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493