MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: NADPH-dependent aldehyde reductase: yqhD
Rattus norvegicus: 2-oxoaldehyde dehydrogenaseInferred from experiment
Saccharomyces cerevisiae: potassium-activated aldehyde dehydrogenase, mitochondrial: ALD4
aldehyde dehydrogenase, mitochondrial: ALD5
magnesium-activated aldehyde dehydrogenase, cytosolic: ALD6

In Pathway: methylglyoxal degradation VIII

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 2-oxoaldehyde dehydrogenase (NADP+)

Enzyme Commission Synonyms: α-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, NADP+-linked α-ketoaldehyde dehydrogenase, 2-ketoaldehyde dehydrogenase, NADP+-dependent α-ketoaldehyde dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -14.563599Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Not identical with EC 2-oxoaldehyde dehydrogenase (NAD+).

Citations: [Ray82, Ray82a]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [an aldehyde + NADP+ + H2O → a carboxylate + NADPH + 2 H+] (
i1: methylglyoxal + NADP+ + H2O → pyruvate + NADPH + 2 H+ (

Unification Links: KEGG:R00205

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Ray82: Ray M, Ray S (1982). "On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase." J Biol Chem 257(18);10571-4. PMID: 7107626

Ray82a: Ray S, Ray M (1982). "Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate." J Biol Chem 257(18);10566-70. PMID: 7107625

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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