Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Forsythia x intermedia: (+)-pinoresinol/(+)-lariciresinol reductaseInferred from experiment: PLR-Fi1

In Pathway: matairesinol biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: (+)-lariciresinol reductase

Enzyme Commission Synonyms: pinoresinol/lariciresinol reductase, pinoresinol-lariciresinol reductases, (+)-pinoresinol/(+)-lariciresinol, (+)-pinoresinol-(+)-lariciresinol reductase, PLR

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.0134888Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The reaction is catalysed in vivo in the opposite direction to that shown. An multifunctional enzyme that also reduces (+)-pinoresinol [EC, (+)-pinoresinol reductase]. Isolated from the plants Forsythia intermedia [Chu93, DinkovaKostova96] Thuja plicata (western red cedar) [Fujita99], Linum perenne (perennial flax) [Hemmati07] and Linum corymbulosum [Bayindir08].

Citations: [Min03]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: Rhea:34423

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Revised 08-Aug-2012 by Caspi R, SRI International


Bayindir08: Bayindir U, Alfermann AW, Fuss E (2008). "Hinokinin biosynthesis in Linum corymbulosum Reichenb." Plant J 55(5);810-20. PMID: 18489708

Chu93: Chu A, Dinkova A, Davin LB, Bedgar DL, Lewis NG (1993). "Stereospecificity of (+)-pinoresinol and (+)-lariciresinol reductases from Forsythia intermedia." J Biol Chem 268(36);27026-33. PMID: 8262939

DinkovaKostova96: Dinkova-Kostova AT, Gang DR, Davin LB, Bedgar DL, Chu A, Lewis NG (1996). "(+)-Pinoresinol/(+)-lariciresinol reductase from Forsythia intermedia. Protein purification, cDNA cloning, heterologous expression and comparison to isoflavone reductase." J Biol Chem 271(46);29473-82. PMID: 8910615

Fujita99: Fujita M, Gang DR, Davin LB, Lewis NG (1999). "Recombinant pinoresinol-lariciresinol reductases from western red cedar (Thuja plicata) catalyze opposite enantiospecific conversions." J Biol Chem 274(2);618-27. PMID: 9872995

Hemmati07: Hemmati S, Schmidt TJ, Fuss E (2007). "(+)-Pinoresinol/(-)-lariciresinol reductase from Linum perenne Himmelszelt involved in the biosynthesis of justicidin B." FEBS Lett 581(4);603-10. PMID: 17257599

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Min03: Min T, Kasahara H, Bedgar DL, Youn B, Lawrence PK, Gang DR, Halls SC, Park H, Hilsenbeck JL, Davin LB, Lewis NG, Kang C (2003). "Crystal structures of pinoresinol-lariciresinol and phenylcoumaran benzylic ether reductases and their relationship to isoflavone reductases." J Biol Chem 278(50);50714-23. PMID: 13129921

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Apr 30, 2016, biocyc13.