Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.23.1.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.23.1.2

Enzymes and Genes:
(+)-pinoresinol/(+)-lariciresinol reductase Inferred from experiment : PLR-Fi1 ( Forsythia x intermedia )

In Pathway: matairesinol biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: (+)-lariciresinol reductase

Enzyme Commission Synonyms: pinoresinol/lariciresinol reductase, pinoresinol-lariciresinol reductases, (+)-pinoresinol/(+)-lariciresinol, (+)-pinoresinol-(+)-lariciresinol reductase, PLR

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.0134888 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The reaction is catalysed in vivo in the opposite direction to that shown. An multifunctional enzyme that also reduces (+)-pinoresinol [EC 1.23.1.1, (+)-pinoresinol reductase]. Isolated from the plants Forsythia intermedia [Chu93a, DinkovaKostova96] Thuja plicata (western red cedar) [Fujita99], Linum perenne (perennial flax) [Hemmati07] and Linum corymbulosum [Bayindir08].

Citations: [Min03]

Gene-Reaction Schematic: ?

Unification Links: Rhea:34423

Relationship Links: BRENDA:EC:1.23.1.2 , ENZYME:EC:1.23.1.2 , IUBMB-ExplorEnz:EC:1.23.1.2

Credits:
Revised 08-Aug-2012 by Caspi R , SRI International


References

Bayindir08: Bayindir U, Alfermann AW, Fuss E (2008). "Hinokinin biosynthesis in Linum corymbulosum Reichenb." Plant J 55(5);810-20. PMID: 18489708

Chu93a: Chu A, Dinkova A, Davin LB, Bedgar DL, Lewis NG (1993). "Stereospecificity of (+)-pinoresinol and (+)-lariciresinol reductases from Forsythia intermedia." J Biol Chem 268(36);27026-33. PMID: 8262939

DinkovaKostova96: Dinkova-Kostova AT, Gang DR, Davin LB, Bedgar DL, Chu A, Lewis NG (1996). "(+)-Pinoresinol/(+)-lariciresinol reductase from Forsythia intermedia. Protein purification, cDNA cloning, heterologous expression and comparison to isoflavone reductase." J Biol Chem 271(46);29473-82. PMID: 8910615

Fujita99: Fujita M, Gang DR, Davin LB, Lewis NG (1999). "Recombinant pinoresinol-lariciresinol reductases from western red cedar (Thuja plicata) catalyze opposite enantiospecific conversions." J Biol Chem 274(2);618-27. PMID: 9872995

Hemmati07: Hemmati S, Schmidt TJ, Fuss E (2007). "(+)-Pinoresinol/(-)-lariciresinol reductase from Linum perenne Himmelszelt involved in the biosynthesis of justicidin B." FEBS Lett 581(4);603-10. PMID: 17257599

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Min03: Min T, Kasahara H, Bedgar DL, Youn B, Lawrence PK, Gang DR, Halls SC, Park H, Hilsenbeck JL, Davin LB, Lewis NG, Kang C (2003). "Crystal structures of pinoresinol-lariciresinol and phenylcoumaran benzylic ether reductases and their relationship to isoflavone reductases." J Biol Chem 278(50);50714-23. PMID: 13129921


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC14B.