Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 1.23.1.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.23.1.2

Enzymes and Genes:
(+)-pinoresinol/(+)-lariciresinol reductase Inferred from experiment : PLR-Fi1 ( Forsythia x intermedia )

In Pathway: matairesinol biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: (+)-lariciresinol reductase

Enzyme Commission Synonyms: pinoresinol/lariciresinol reductase, pinoresinol-lariciresinol reductases, (+)-pinoresinol/(+)-lariciresinol, (+)-pinoresinol-(+)-lariciresinol reductase, PLR

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.0134888 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The reaction is catalysed in vivo in the opposite direction to that shown. An multifunctional enzyme that also reduces (+)-pinoresinol [EC 1.23.1.1, (+)-pinoresinol reductase]. Isolated from the plants Forsythia intermedia [Chu93, DinkovaKostova96] Thuja plicata (western red cedar) [Fujita99], Linum perenne (perennial flax) [Hemmati07] and Linum corymbulosum [Bayindir08].

Citations: [Min03]

Gene-Reaction Schematic: ?

Unification Links: Rhea:34423

Relationship Links: BRENDA:EC:1.23.1.2 , ENZYME:EC:1.23.1.2 , IUBMB-ExplorEnz:EC:1.23.1.2

Credits:
Revised 08-Aug-2012 by Caspi R , SRI International


References

Bayindir08: Bayindir U, Alfermann AW, Fuss E (2008). "Hinokinin biosynthesis in Linum corymbulosum Reichenb." Plant J 55(5);810-20. PMID: 18489708

Chu93: Chu A, Dinkova A, Davin LB, Bedgar DL, Lewis NG (1993). "Stereospecificity of (+)-pinoresinol and (+)-lariciresinol reductases from Forsythia intermedia." J Biol Chem 268(36);27026-33. PMID: 8262939

DinkovaKostova96: Dinkova-Kostova AT, Gang DR, Davin LB, Bedgar DL, Chu A, Lewis NG (1996). "(+)-Pinoresinol/(+)-lariciresinol reductase from Forsythia intermedia. Protein purification, cDNA cloning, heterologous expression and comparison to isoflavone reductase." J Biol Chem 271(46);29473-82. PMID: 8910615

Fujita99: Fujita M, Gang DR, Davin LB, Lewis NG (1999). "Recombinant pinoresinol-lariciresinol reductases from western red cedar (Thuja plicata) catalyze opposite enantiospecific conversions." J Biol Chem 274(2);618-27. PMID: 9872995

Hemmati07: Hemmati S, Schmidt TJ, Fuss E (2007). "(+)-Pinoresinol/(-)-lariciresinol reductase from Linum perenne Himmelszelt involved in the biosynthesis of justicidin B." FEBS Lett 581(4);603-10. PMID: 17257599

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Min03: Min T, Kasahara H, Bedgar DL, Youn B, Lawrence PK, Gang DR, Halls SC, Park H, Hilsenbeck JL, Davin LB, Lewis NG, Kang C (2003). "Crystal structures of pinoresinol-lariciresinol and phenylcoumaran benzylic ether reductases and their relationship to isoflavone reductases." J Biol Chem 278(50);50714-23. PMID: 13129921


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, biocyc14.