|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
Enzymes and Genes:
|Linum perenne :||(+)-pinoresinol/(-)-lariciresinol reductase
|Thuja plicata :||(+)-pinoresinol/(+)-lariciresinol reductase
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: (–)-lariciresinol reductase
Enzyme Commission Synonyms: pinoresinol/lariciresinol reductase, pinoresinol-lariciresinol reductases, (-)-pinoresinol-(-)-lariciresinol reductase, PLR
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -1.0134888 [Latendresse13]
Enzyme Commission Summary:
The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that also reduces (-)-pinoresinol [EC 184.108.40.206, (-)-pinoresinol reductase]. Isolated from the plants Thuja plicata (western red cedar) [Fujita99] and Linum corymbulosum [Hemmati07] .
Fujita99: Fujita M, Gang DR, Davin LB, Lewis NG (1999). "Recombinant pinoresinol-lariciresinol reductases from western red cedar (Thuja plicata) catalyze opposite enantiospecific conversions." J Biol Chem 274(2);618-27. PMID: 9872995
Hemmati07: Hemmati S, Schmidt TJ, Fuss E (2007). "(+)-Pinoresinol/(-)-lariciresinol reductase from Linum perenne Himmelszelt involved in the biosynthesis of justicidin B." FEBS Lett 581(4);603-10. PMID: 17257599
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