MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Sphingobium fuliginis: organophosphate acid anhydraseInferred from experiment: opd

In Pathway: paraoxon degradation

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aryldialkylphosphatase

Enzyme Commission Synonyms: organophosphate hydrolase, paraoxonase, A-esterase, aryltriphosphatase, organophosphate esterase, esterase B1, esterase E4, paraoxon esterase, pirimiphos-methyloxon esterase, OPA anhydrase, organophosphorus hydrolase, phosphotriesterase, paraoxon hydrolase, OPH, organophosphorus acid anhydrase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 3.5787811Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC arylesterase.

Citations: [Mackness87, ALDRIDGE53, Bosmann72, MAIN60, Reiner89]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R05548

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


ALDRIDGE53: ALDRIDGE WN (1953). "Serum esterases. I. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination." Biochem J 53(1);110-7. PMID: 13032041

Bosmann72: Bosmann HB (1972). "Membrane marker enzymes. Characterization of an arylesterase of guinea pig cerebral cortex utilizing p-nitrophenyl acetate as substrate." Biochim Biophys Acta 276(1);180-91. PMID: 5047702

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Mackness87: Mackness MI, Thompson HM, Hardy AR, Walker CH (1987). "Distinction between 'A'-esterases and arylesterases. Implications for esterase classification." Biochem J 245(1);293-6. PMID: 2822017

MAIN60: MAIN AR (1960). "The differentiation of the A-type esterases in sheep serum." Biochem J 75;188-95. PMID: 14420012

Reiner89: Reiner, E., Aldridge, W.N, Hoskin, C.G (1989). "Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood, Chichester, UK,."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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