MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Sphingobium fuliginis : organophosphate acid anhydrase Inferred from experiment : opd

In Pathway: paraoxon degradation

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aryldialkylphosphatase

Enzyme Commission Synonyms: organophosphate hydrolase, paraoxonase, A-esterase, aryltriphosphatase, organophosphate esterase, esterase B1, esterase E4, paraoxon esterase, pirimiphos-methyloxon esterase, OPA anhydrase, organophosphorus hydrolase, phosphotriesterase, paraoxon hydrolase, OPH, organophosphorus acid anhydrase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 3.5787811 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC arylesterase.

Citations: [Mackness87, ALDRIDGE53, Bosmann72, MAIN60, Reiner89]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R05548

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


ALDRIDGE53: ALDRIDGE WN (1953). "Serum esterases. I. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination." Biochem J 53(1);110-7. PMID: 13032041

Bosmann72: Bosmann HB (1972). "Membrane marker enzymes. Characterization of an arylesterase of guinea pig cerebral cortex utilizing p-nitrophenyl acetate as substrate." Biochim Biophys Acta 276(1);180-91. PMID: 5047702

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Mackness87: Mackness MI, Thompson HM, Hardy AR, Walker CH (1987). "Distinction between 'A'-esterases and arylesterases. Implications for esterase classification." Biochem J 245(1);293-6. PMID: 2822017

MAIN60: MAIN AR (1960). "The differentiation of the A-type esterases in sheep serum." Biochem J 75;188-95. PMID: 14420012

Reiner89: Reiner, E., Aldridge, W.N, Hoskin, C.G (1989). "Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood, Chichester, UK,."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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