|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 184.108.40.206
Enzymes and Genes:
|Sphingobium fuliginis:||organophosphate acid anhydrase: opd|
In Pathway: paraoxon degradation
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: aryldialkylphosphatase
Enzyme Commission Synonyms: organophosphate hydrolase, paraoxonase, A-esterase, aryltriphosphatase, organophosphate esterase, esterase B1, esterase E4, paraoxon esterase, pirimiphos-methyloxon esterase, OPA anhydrase, organophosphorus hydrolase, phosphotriesterase, paraoxon hydrolase, OPH, organophosphorus acid anhydrase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 3.5787811 [Latendresse13]
Enzyme Commission Summary:
Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC 220.127.116.11 arylesterase.
Unification Links: KEGG:R05548
ALDRIDGE53: ALDRIDGE WN (1953). "Serum esterases. I. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination." Biochem J 53(1);110-7. PMID: 13032041
Bosmann72: Bosmann HB (1972). "Membrane marker enzymes. Characterization of an arylesterase of guinea pig cerebral cortex utilizing p-nitrophenyl acetate as substrate." Biochim Biophys Acta 276(1);180-91. PMID: 5047702
Mackness87: Mackness MI, Thompson HM, Hardy AR, Walker CH (1987). "Distinction between 'A'-esterases and arylesterases. Implications for esterase classification." Biochem J 245(1);293-6. PMID: 2822017
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