Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 3.1.3.73

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.3.73

Enzymes and Genes:
predicted adenosylcobalamin phosphatase/α-ribazole phosphatase Inferred by curator : cobC ( Escherichia coli K-12 substr. MG1655 )
α-ribazole-5'-phosphate phosphatase Inferred from experiment : cobZ ( Methanosarcina mazei Go1 )
adenosylcobalamin 5'-phosphate phosphatase Inferred from experiment : cbiS ( Methanopyrus kandleri AV19 )
α-ribazole-5'-phosphate phosphatase Inferred from experiment : cobC ( Salmonella enterica enterica serovar Typhimurium )

In Pathway: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I , adenosylcobalamin salvage from cobinamide I , adenosylcobalamin salvage from cobinamide II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: adenosylcobalamin/α-ribazole phosphatase

Enzyme Commission Synonyms: CobC, adenosylcobalamin phosphatase, α-ribazole phosphatase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 4.4085083 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme catalyses the last step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, characterized in Salmonella enterica [Zayas07]. It also participates in a salvage pathway that recycles cobinamide into adenosylcobalamin [OToole94].

Citations: [Warren02]

Gene-Reaction Schematic: ?

Unification Links: Rhea:30370

Relationship Links: BRENDA:EC:3.1.3.73 , ENZYME:EC:3.1.3.73 , IUBMB-ExplorEnz:EC:3.1.3.73

Credits:
Revised 03-Nov-2010 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

OToole94: O'Toole GA, Trzebiatowski JR, Escalante-Semerena JC (1994). "The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin." J Biol Chem 1994;269(42);26503-11. PMID: 7929373

Warren02: Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)." Nat Prod Rep 19(4);390-412. PMID: 12195810

Zayas07: Zayas CL, Escalante-Semerena JC (2007). "Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway." J Bacteriol 189(6);2210-8. PMID: 17209023


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, biocyc14.