|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
Enzymes and Genes:
predicted adenosylcobalamin phosphatase/α-ribazole phosphatase : cobC ( Escherichia coli K-12 substr. MG1655 )
α-ribazole-5'-phosphate phosphatase : cobZ ( Methanosarcina mazei Go1 )
adenosylcobalamin 5'-phosphate phosphatase : cbiS ( Methanopyrus kandleri AV19 )
α-ribazole-5'-phosphate phosphatase : cobC ( Salmonella enterica enterica serovar Typhimurium )
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: adenosylcobalamin/α-ribazole phosphatase
Enzyme Commission Synonyms: CobC, adenosylcobalamin phosphatase, α-ribazole phosphatase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 4.4085083 [Latendresse13]
Enzyme Commission Summary:
This enzyme catalyses the last step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, characterized in Salmonella enterica [Zayas07]. It also participates in a salvage pathway that recycles cobinamide into adenosylcobalamin [OToole94].
Unification Links: Rhea:30370
OToole94: O'Toole GA, Trzebiatowski JR, Escalante-Semerena JC (1994). "The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin." J Biol Chem 1994;269(42);26503-11. PMID: 7929373
Zayas07: Zayas CL, Escalante-Semerena JC (2007). "Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway." J Bacteriol 189(6);2210-8. PMID: 17209023
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