MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655 : predicted adenosylcobalamin phosphatase/α-ribazole phosphatase Inferred by curator : cobC
Methanopyrus kandleri AV19 : adenosylcobalamin 5'-phosphate phosphatase Inferred from experiment : cbiS
Methanosarcina mazei Go1 : α-ribazole-5'-phosphate phosphatase Inferred from experiment : cobZ
Salmonella enterica enterica serovar Typhimurium : α-ribazole-5'-phosphate phosphatase Inferred from experiment : cobC

In Pathway: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I , adenosylcobalamin salvage from cobinamide I , adenosylcobalamin salvage from cobinamide II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: adenosylcobalamin/α-ribazole phosphatase

Enzyme Commission Synonyms: CobC, adenosylcobalamin phosphatase, α-ribazole phosphatase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 7.217041 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme catalyses the last step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, characterized in Salmonella enterica [Zayas07]. It also participates in a salvage pathway that recycles cobinamide into adenosylcobalamin [OToole94].

Citations: [Warren02]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: Rhea:30370

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Revised 03-Nov-2010 by Caspi R , SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

OToole94: O'Toole GA, Trzebiatowski JR, Escalante-Semerena JC (1994). "The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin." J Biol Chem 1994;269(42);26503-11. PMID: 7929373

Warren02: Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)." Nat Prod Rep 19(4);390-412. PMID: 12195810

Zayas07: Zayas CL, Escalante-Semerena JC (2007). "Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway." J Bacteriol 189(6);2210-8. PMID: 17209023

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Thu Oct 8, 2015, biocyc13.