Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.1.3.73

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.3.73

Enzymes and Genes:
predicted adenosylcobalamin phosphatase/α-ribazole phosphatase Inferred by curator : cobC ( Escherichia coli K-12 substr. MG1655 )
α-ribazole-5'-phosphate phosphatase Inferred from experiment : cobZ ( Methanosarcina mazei Go1 )
adenosylcobalamin 5'-phosphate phosphatase Inferred from experiment : cbiS ( Methanopyrus kandleri AV19 )
α-ribazole-5'-phosphate phosphatase Inferred from experiment : cobC ( Salmonella enterica enterica serovar Typhimurium )

In Pathway: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I , adenosylcobalamin salvage from cobinamide I , adenosylcobalamin salvage from cobinamide II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: adenosylcobalamin/α-ribazole phosphatase

Enzyme Commission Synonyms: CobC, adenosylcobalamin phosphatase, α-ribazole phosphatase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 4.4085083 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme catalyses the last step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, characterized in Salmonella enterica [Zayas07]. It also participates in a salvage pathway that recycles cobinamide into adenosylcobalamin [OToole94].

Citations: [Warren02]

Gene-Reaction Schematic: ?

Unification Links: Rhea:30370

Relationship Links: BRENDA:EC:3.1.3.73 , ENZYME:EC:3.1.3.73 , IUBMB-ExplorEnz:EC:3.1.3.73

Credits:
Revised 03-Nov-2010 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

OToole94: O'Toole GA, Trzebiatowski JR, Escalante-Semerena JC (1994). "The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin." J Biol Chem 1994;269(42);26503-11. PMID: 7929373

Warren02: Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)." Nat Prod Rep 19(4);390-412. PMID: 12195810

Zayas07: Zayas CL, Escalante-Semerena JC (2007). "Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway." J Bacteriol 189(6);2210-8. PMID: 17209023


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC13A.