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MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: predicted adenosylcobalamin phosphatase/α-ribazole phosphataseInferred by curator: cobC
Methanopyrus kandleri AV19: adenosylcobalamin 5'-phosphate phosphataseInferred from experiment: cbiS
Methanosarcina mazei Go1: α-ribazole-5'-phosphate phosphataseInferred from experiment: cobZ
Salmonella enterica enterica serovar Typhimurium: α-ribazole-5'-phosphate phosphataseInferred from experiment: cobC

In Pathway: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I, adenosylcobalamin salvage from cobinamide I, adenosylcobalamin salvage from cobinamide II

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: adenosylcobalamin/α-ribazole phosphatase

Enzyme Commission Synonyms: CobC, adenosylcobalamin phosphatase, α-ribazole phosphatase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 7.217041Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme catalyses the last step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, characterized in Salmonella enterica [Zayas07]. It also participates in a salvage pathway that recycles cobinamide into adenosylcobalamin [OToole94].

Citations: [Warren02]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: Rhea:30370

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Revised 03-Nov-2010 by Caspi R, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

OToole94: O'Toole GA, Trzebiatowski JR, Escalante-Semerena JC (1994). "The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin." J Biol Chem 1994;269(42);26503-11. PMID: 7929373

Warren02: Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)." Nat Prod Rep 19(4);390-412. PMID: 12195810

Zayas07: Zayas CL, Escalante-Semerena JC (2007). "Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway." J Bacteriol 189(6);2210-8. PMID: 17209023

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Sun May 1, 2016, BIOCYC11A.