Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

MetaCyc Reaction: 1.14.13.69

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.14.13.69

Enzymes and Genes:
alkene monooxygenase Inferred from experiment : aamA , aamE , aamB , aamF , aamC , aamD ( Xanthobacter autotrophicus Py2 )

In Pathway: propylene degradation

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: alkene monooxygenase

Enzyme Commission Synonyms: alkene epoxygenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -91.19881 Inferred by computational analysis [Latendresse13]

Summary:
The enzyme from Xanthobacter sp. strain Py2 is a multicomponent enzyme comprising (1) an NADH reductase, which provides the reductant for O(2) activation; (2) a Rieske-type ferredoxin, which is an electron-transfer protein; (3) an oxygenase, which contains the catalytic centre for alkene epoxidation and 4) a small protein of unknown function that is essential for activity.

Enzyme Commission Summary:
The enzyme from Xanthobacter sp. strain Py2 is a multicomponent enzyme comprising (1) an NADH reductase, which provides the reductant for O(2) activation; (2) a Rieske-type ferredoxin, which is an electron-transfer protein; (3) an oxygenase, which contains the catalytic centre for alkene epoxidation and 4) a small protein of unknown function that is essential for activity.

Citations: [Small97, Zhou99a, Gallagher97]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R05730

Relationship Links: BRENDA:EC:1.14.13.69 , ENZYME:EC:1.14.13.69 , IUBMB-ExplorEnz:EC:1.14.13.69


References

Gallagher97: Gallagher SC, Cammack R, Dalton H (1997). "Alkene monooxygenase from Nocardia corallina B-276 is a member of the class of dinuclear iron proteins capable of stereospecific epoxygenation reactions." Eur J Biochem 247(2);635-41. PMID: 9266707

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Small97: Small FJ, Ensign SA (1997). "Alkene monooxygenase from Xanthobacter strain Py2. Purification and characterization of a four-component system central to the bacterial metabolism of aliphatic alkenes." J Biol Chem 272(40);24913-20. PMID: 9312093

Zhou99a: Zhou NY, Jenkins A, Chan Kwo Chion CK, Leak DJ (1999). "The alkene monooxygenase from Xanthobacter strain Py2 is closely related to aromatic monooxygenases and catalyzes aromatic monohydroxylation of benzene, toluene, and phenol." Appl Environ Microbiol 65(4);1589-95. PMID: 10103255


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, biocyc14.