|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
Enzymes and Genes:
|Bifidobacterium longum :||N-acetylhexosamine kinase
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: N-acetylhexosamine 1-kinase
Enzyme Commission Synonyms: NahK, LnpB, N-acetylgalactosamine/N-acetylglucosamine 1-kinase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -14.815857 [Latendresse13]
Enzyme Commission Summary:
Differs from EC 184.108.40.206, N-acetylgalactosamine kinase, as it can phosphorylate both N-acetyl-α-D-galactosamine and N-acetyl-β-D-glucosamine at similar rates. Also has some activity with N-acetyl-β-D-mannosamine, D-talose and D-mannose as substrate. ATP can be replaced by GTP or ITP but with decreased enzyme activity. Requires a divalent cation, with Mg2+ resulting in by far the greatest stimulation of enzyme activity [Nishimoto07].
Instance reaction of [an N-acetyl-D-hexosamine + ATP = an N-acetyl-α-D-hexosamine 1-phosphate + ADP + H+] (220.127.116.11):
i1: ATP + N-acetyl-α-D-galactosamine = ADP + N-acetyl-α-D-galactosamine 1-phosphate + H+ (18.104.22.168)
Unification Links: Rhea:25428
Nishimoto07: Nishimoto M, Kitaoka M (2007). "Identification of N-acetylhexosamine 1-kinase in the complete lacto-N-biose I/galacto-N-biose metabolic pathway in Bifidobacterium longum." Appl Environ Microbiol 73(20);6444-9. PMID: 17720833
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