Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.7.1.162

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.1.162

Enzymes and Genes:
N-acetylhexosamine kinase Inferred from experiment : lnpB ( Bifidobacterium longum )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reaction:
ATP + N-acetyl-α-D-galactosamine = ADP + N-acetyl-α-D-galactosamine 1-phosphate + H+ (2.7.1.157)

Enzyme Commission Primary Name: N-acetylhexosamine 1-kinase

Enzyme Commission Synonyms: NahK, LnpB, N-acetylgalactosamine/N-acetylglucosamine 1-kinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -14.815857 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Differs from EC 2.7.1.157, N-acetylgalactosamine kinase, as it can phosphorylate both N-acetyl-α-D-galactosamine and N-acetyl-β-D-glucosamine at similar rates. Also has some activity with N-acetyl-β-D-mannosamine, D-talose and D-mannose as substrate. ATP can be replaced by GTP or ITP but with decreased enzyme activity. Requires a divalent cation, with Mg2+ resulting in by far the greatest stimulation of enzyme activity [Nishimoto07].

Gene-Reaction Schematic: ?

Instance reaction of [an N-acetyl-D-hexosamine + ATP = an N-acetyl-α-D-hexosamine 1-phosphate + ADP + H+] (2.7.1.162):
i1: ATP + N-acetyl-α-D-galactosamine = ADP + N-acetyl-α-D-galactosamine 1-phosphate + H+ (2.7.1.157)

Unification Links: Rhea:25428

Relationship Links: BRENDA:EC:2.7.1.162 , ENZYME:EC:2.7.1.162 , IUBMB-ExplorEnz:EC:2.7.1.162


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nishimoto07: Nishimoto M, Kitaoka M (2007). "Identification of N-acetylhexosamine 1-kinase in the complete lacto-N-biose I/galacto-N-biose metabolic pathway in Bifidobacterium longum." Appl Environ Microbiol 73(20);6444-9. PMID: 17720833


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC13B.