|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
Enzymes and Genes:
|Streptomyces coelicolor A3(2) :||epi-isozizaene 5-monooxygenase
In Pathway: albaflavenone biosynthesis
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -95.94052 [Latendresse13]
This cytochrome-P450 enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses two sequential allylic oxidation reactions. The substrate (+)-epi-isozizaene, which is formed by the action of EC 22.214.171.124, epi-isozizaene synthase, is first oxidized to yield the epimeric intermediates ((5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone.
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