MetaCyc Reaction: [no EC number assigned]

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

Enzymes and Genes:

Streptomyces coelicolor A3(2): epi-isozizaene 5-monooxygenaseInferred from experiment: SCO5223

Sub-reaction of: (+)-epi-isozizaene + 2 NADPH + 2 H+ + 2 oxygen → albaflavenone + 2 NADP+ + 3 H2O

In Pathway: albaflavenone biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Standard Gibbs Free Energy (ΔrG): -95.94052 kcal/molInferred by computational analysis [Latendresse13]

This cytochrome-P450 enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses two sequential allylic oxidation reactions. The substrate (+)-epi-isozizaene, which is formed by the action of EC, epi-isozizaene synthase, is first oxidized to yield the epimeric intermediates ( (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone.

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R08851, Rhea:25976


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 20.0 (software by SRI International) on Fri May 6, 2016, BIOCYC13A.