|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
Enzymes and Genes:
|Streptomyces coelicolor A3(2):||epi-isozizaene 5-monooxygenase: SCO5223|
In Pathway: albaflavenone biosynthesis
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Standard Gibbs Free Energy (ΔrG'°): -95.94052 kcal/mol [Latendresse13]
This cytochrome-P450 enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses two sequential allylic oxidation reactions. The substrate (+)-epi-isozizaene, which is formed by the action of EC 18.104.22.168, epi-isozizaene synthase, is first oxidized to yield the epimeric intermediates ( (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone.
©2016 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493