MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Mycobacterium tuberculosis H37Rv : halimadienyl-diphosphate synthase Inferred from experiment : Rv3377c

In Pathway: tuberculosinol biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: halimadienyl-diphosphate synthase

Enzyme Commission Synonyms: Rv3377c, halimadienyl diphosphate synthase, tuberculosinol diphosphate synthase, halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -42.25 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Mg2+ for activity. This enzyme is found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity. The product of the reaction is subsequently dephosphorylated yielding tuberculosinol [halima-5(6),13-dien-15-ol].

Citations: [Nakano05]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: Rhea:25624

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Revised 05-Aug-2009 by Caspi R , SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nakano05: Nakano C, Okamura T, Sato T, Dairi T, Hoshino T (2005). "Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton." Chem Commun (Camb) NIL(8);1016-8. PMID: 15719101

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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