|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
In Pathway: tuberculosinol biosynthesis
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: halimadienyl-diphosphate synthase
Enzyme Commission Synonyms: Rv3377c, halimadienyl diphosphate synthase, tuberculosinol diphosphate synthase, halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -42.25 [Latendresse13]
Enzyme Commission Summary:
Requires Mg2+ for activity. This enzyme is found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity. The product of the reaction is subsequently dephosphorylated yielding tuberculosinol [halima-5(6),13-dien-15-ol].
Unification Links: Rhea:25624
Nakano05: Nakano C, Okamura T, Sato T, Dairi T, Hoshino T (2005). "Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton." Chem Commun (Camb) NIL(8);1016-8. PMID: 15719101
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