Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 5.5.1.16

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 5.5.1.16

Enzymes and Genes:
halimadienyl-diphosphate synthase Inferred from experiment : Rv3377c ( Mycobacterium tuberculosis H37Rv )

In Pathway: tuberculosinol biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: halimadienyl-diphosphate synthase

Enzyme Commission Synonyms: Rv3377c, halimadienyl diphosphate synthase, tuberculosinol diphosphate synthase, halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -42.25 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Mg2+ for activity. This enzyme is found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity. The product of the reaction is subsequently dephosphorylated yielding tuberculosinol [halima-5(6),13-dien-15-ol].

Citations: [Nakano05]

Gene-Reaction Schematic: ?

Unification Links: Rhea:25624

Relationship Links: BRENDA:EC:5.5.1.16 , ENZYME:EC:5.5.1.16 , IUBMB-ExplorEnz:EC:5.5.1.16

Credits:
Revised 05-Aug-2009 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nakano05: Nakano C, Okamura T, Sato T, Dairi T, Hoshino T (2005). "Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton." Chem Commun (Camb) NIL(8);1016-8. PMID: 15719101


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, biocyc14.