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MetaCyc Reaction: 5.5.1.16

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 5.5.1.16

Enzymes and Genes:

Mycobacterium tuberculosis H37Rv: halimadienyl-diphosphate synthaseInferred from experiment: Rv3377c

In Pathway: tuberculosinol biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: halimadienyl-diphosphate synthase

Enzyme Commission Synonyms: Rv3377c, halimadienyl diphosphate synthase, tuberculosinol diphosphate synthase, halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -42.25Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Mg2+ for activity. This enzyme is found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity. The product of the reaction is subsequently dephosphorylated yielding tuberculosinol [halima-5(6),13-dien-15-ol].

Citations: [Nakano05]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: Rhea:25624

Relationship Links: BRENDA:EC:5.5.1.16, ENZYME:EC:5.5.1.16, IUBMB-ExplorEnz:EC:5.5.1.16

Credits:
Revised 05-Aug-2009 by Caspi R, SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nakano05: Nakano C, Okamura T, Sato T, Dairi T, Hoshino T (2005). "Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton." Chem Commun (Camb) NIL(8);1016-8. PMID: 15719101


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Apr 30, 2016, biocyc11.